Ifnb1 interferon beta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ifnb1provided by RGD
Official Full Name: interferon beta 1provided by RGD
Primary source: RGD:2865
See related: EnsemblRapid:ENSRNOG00000006268 AllianceGenome:RGD:2865
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ifnb; If1da1
Summary: Predicted to enable chloramphenicol O-acetyltransferase activity; cytokine activity; and type I interferon receptor binding activity. Involved in several processes, including cellular response to dsDNA; cellular response to exogenous dsRNA; and regulation of gene expression. Predicted to be active in extracellular space. Used to study proteinuria and transient cerebral ischemia. Human ortholog(s) of this gene implicated in COVID-19; cerebral infarction; multiple sclerosis; and retinoblastoma. Orthologous to human IFNB1 (interferon beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: 5q32

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (108066650..108067487, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (103020758..103021595, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (106865192..106865746, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In cardiac fibroblasts, interferon-beta attenuates differentiation, collagen synthesis, and TGF-beta1-induced collagen gel contraction.
Title: In cardiac fibroblasts, interferon-beta attenuates differentiation, collagen synthesis, and TGF-β1-induced collagen gel contraction.
results provided evidence that delivery of IL-18 and IFN-beta by BMSCs may be an excellent and promising approach to develop an effective treatment protocol for glioma therapy.
Title: Bone marrow-derived mesenchymal stem cells co-expressing interleukin-18 and interferon-β exhibit potent antitumor effect against intracranial glioma in rats.
IFN-gamma is able to activate rat intestinal mucous microvascular endothelial cells, thereby leading to upregulated expressions of IFN-alpha/beta.
Title: IFN-γ induces IFN-α and IFN-β expressions in cultured rat intestinal mucosa microvascular endothelial cells.
This study presents novel effects of IFN-beta in the central nervous system and begins to unravel the mechanism behind the known excitability changes in neurons.
Title: Interferon-beta modulates protein synthesis in the central nervous system.
These findings validate IFN-beta as a therapeutic molecule for intraarticular gene therapy of arthritis.
Title: Intraarticular interferon-beta gene therapy ameliorates adjuvant arthritis in rats.

Submit: New GeneRIF Correction

General gene information

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Markers

RH94433 (e-PCR)
- UniSTS:119681

PMC26775P1 (e-PCR)
- UniSTS:272352

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chloramphenicol O-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor binding	ISO Inferred from Sequence Orthology more info
enables type I interferon receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type I interferon receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in T cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adaptive immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to dexamethasone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dsDNA	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to dsRNA	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to dsRNA	ISO Inferred from Sequence Orthology more info
involved_in cellular response to exogenous dsRNA	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to virus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum unfolded protein response	IEP Inferred from Expression Pattern more info	PubMed
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within humoral immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in natural killer cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Lewy body formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Lewy body formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 2 cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood-brain barrier permeability	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell adhesion molecule production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of immunoglobulin production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of matrix metallopeptidase secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mononuclear cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuroinflammatory response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in response to exogenous dsRNA	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon beta

Names: IFN-beta; interferon 1da1; interferon beta 1, fibroblast

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.