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    Get4 guided entry of tail-anchored proteins factor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288518, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Get4provided by RGD
    Official Full Name
    guided entry of tail-anchored proteins factor 4provided by RGD
    Primary source
    RGD:1311660
    See related
    EnsemblRapid:ENSRNOG00000001299 AllianceGenome:RGD:1311660
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cee; RGD1311660
    Summary
    Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in several processes, including cytoplasmic sequestering of protein; establishment of protein localization to membrane; and proteolysis involved in protein catabolic process. Predicted to be located in chromosome; cytoplasm; and nuclear lumen. Predicted to be part of BAT3 complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human GET4 (guided entry of tail-anchored proteins factor 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 48.3), Heart (RPKM 32.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Get4 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (20490861..20508096, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (15377009..15394238, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (17469112..17486709, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase assembly factor COX19 Neighboring gene ArfGAP with dual PH domains 1 Neighboring gene uncharacterized LOC102547493 Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene dynein, axonemal, assembly factor 5 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35. Mock JY, et al. Proc Natl Acad Sci U S A, 2017 Oct 31. PMID 29042515, Free PMC Article
    2. A ribosome-associating factor chaperones tail-anchored membrane proteins. Mariappan M, et al. Nature, 2010 Aug 26. PMID 20676083, Free PMC Article
    3. Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain. Mock JY, et al. Proc Natl Acad Sci U S A, 2015 Jan 6. PMID 25535373, Free PMC Article
    4. A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation. Wang Q, et al. Mol Cell, 2011 Jun 24. PMID 21636303, Free PMC Article
    5. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, et al. PLoS Genet, 2016 May. PMID 27191843, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic sequestering of protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of unfolded protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein targeting to endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into ER membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of BAT3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BAT3 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Golgi to ER traffic protein 4 homolog
    Names
    conserved edge expressed protein
    golgi to ER traffic protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163320.1 → NP_001156792.1  Golgi to ER traffic protein 4 homolog

      See identical proteins and their annotated locations for NP_001156792.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6A965, A6K1X1, F1LXF5
      Related
      ENSRNOP00000088319.1, ENSRNOT00000108209.2
      Conserved Domains (1) summary
      pfam04190
      Location:59 → 295
      DUF410; Protein of unknown function (DUF410)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      20490861..20508096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248927.5 → XP_006248989.1  Golgi to ER traffic protein 4 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6A965
      Conserved Domains (1) summary
      pfam04190
      Location:59 → 294
      DUF410; Protein of unknown function (DUF410)

    RNA

    1. XR_010056369.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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