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    Traip TRAF-interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 22036, updated on 4-Jan-2025

    Summary

    Official Symbol
    Traipprovided by MGI
    Official Full Name
    TRAF-interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1096377
    See related
    Ensembl:ENSMUSG00000032586 AllianceGenome:MGI:1096377
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trip
    Summary
    Enables ubiquitin protein ligase activity. Involved in negative regulation of interferon-beta production and protein ubiquitination. Acts upstream of or within negative regulation of NF-kappaB transcription factor activity and signal transduction. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus and site of DNA damage. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina layer; and spleen. Human ortholog(s) of this gene implicated in Seckel syndrome 9. Orthologous to human TRAIP (TRAF interacting protein). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in CNS E11.5 (RPKM 3.7), frontal lobe adult (RPKM 3.7) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Traip in Genome Data Viewer
    Location:
    9 F1; 9 59.07 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107828158..107849469)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107950325..107972270)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene actin-like 11 Neighboring gene CaM kinase-like vesicle-associated Neighboring gene STARR-positive B cell enhancer ABC_E3858 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107878063-107878250 Neighboring gene STARR-positive B cell enhancer ABC_E2913 Neighboring gene ubiquitin-like modifier activating enzyme 7 Neighboring gene inka box actin regulator 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding  
    enables identical protein binding  
    enables metal ion binding  
    enables protein binding PubMed 
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity PubMed 
    enables ubiquitin-protein transferase activity PubMed 
    enables ubiquitin-protein transferase activity  
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response  
    acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity PubMed 
    involved_in negative regulation of interferon-beta production PubMed 
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination PubMed 
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in protein-DNA covalent cross-linking repair  
    involved_in replication fork processing  
    involved_in replication fork processing  
    involved_in replication fork processing  
    acts_upstream_of_or_within signal transduction PubMed 
    acts_upstream_of_or_within signal transduction PubMed 
    Component Evidence Code Pubs
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in perinuclear region of cytoplasm  
    is_active_in site of DNA damage  
    located_in site of DNA damage  
    located_in site of DNA damage  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRAIP
    Names
    RING-type E3 ubiquitin transferase TRAIP
    NP_001397399.1
    NP_001397400.1
    NP_001397401.1
    NP_001397402.1
    NP_035764.2
    XP_017168773.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410470.1NP_001397399.1  E3 ubiquitin-protein ligase TRAIP isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL731808
    2. NM_001410471.1NP_001397400.1  E3 ubiquitin-protein ligase TRAIP isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL731808
    3. NM_001410472.1NP_001397401.1  E3 ubiquitin-protein ligase TRAIP isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL731808
    4. NM_001410473.1NP_001397402.1  E3 ubiquitin-protein ligase TRAIP isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL731808
    5. NM_011634.4NP_035764.2  E3 ubiquitin-protein ligase TRAIP isoform 1

      See identical proteins and their annotated locations for NP_035764.2

      Status: VALIDATED

      Source sequence(s)
      AL731808
      Consensus CDS
      CCDS23511.1
      UniProtKB/Swiss-Prot
      O08854, Q8VIG6, Q922M8, Q9CPP4
      Related
      ENSMUSP00000040001.4, ENSMUST00000049348.9
      Conserved Domains (2) summary
      pfam08647
      Location:204271
      BRE1; BRE1 E3 ubiquitin ligase
      pfam13639
      Location:750
      zf-RING_2; Ring finger domain

    RNA

    1. NR_177076.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL731808

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107828158..107849469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313284.2XP_017168773.1  E3 ubiquitin-protein ligase TRAIP isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:6150
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
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