Snx9 sorting nexin 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snx9provided by MGI
Official Full Name: sorting nexin 9provided by MGI
Primary source: MGI:MGI:1913866
See related: Ensembl:ENSMUSG00000002365 AllianceGenome:MGI:1913866
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SDP1; SH3PX1; 2700073N08Rik
Summary: Enables phosphatidylinositol binding activity. Involved in positive regulation of actin filament polymerization. Acts upstream of or within intracellular protein transport. Located in cytoplasm and plasma membrane. Is active in cytosol. Colocalizes with cuticular plate. Is expressed in lower jaw molar and upper jaw molar. Orthologous to human SNX9 (sorting nexin 9). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Ubiquitous expression in placenta adult (RPKM 37.0), large intestine adult (RPKM 23.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A1; 17 3.51 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (5891599..5982231)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (5841324..5931956)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Snx9-deficient mice do not show defects in development as well as auditory function, suggesting that SNX9 is not essential for mice development and hearing
Title: Sorting nexin 9 (SNX9) is not essential for development and auditory function in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info
enables Arp2/3 complex binding	IEA Inferred from Electronic Annotation more info
enables Arp2/3 complex binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cleavage furrow formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cleavage furrow formation	ISO Inferred from Sequence Orthology more info
involved_in cleavage furrow formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosomal transport	ISO Inferred from Sequence Orthology more info
involved_in endosomal transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in lipid tube assembly	ISO Inferred from Sequence Orthology more info
involved_in lipid tube assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma membrane tubulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane tubulation	IEA Inferred from Electronic Annotation more info
involved_in plasma membrane tubulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
colocalizes_with clathrin-coated vesicle	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with cuticular plate	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IPI Inferred from Physical Interaction more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sorting nexin-9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025664.6 → NP_079940.2 sorting nexin-9

Status: VALIDATED

Source sequence(s)

AC168063, AK155830

Consensus CDS

CCDS57041.1

UniProtKB/Swiss-Prot

Q91VH2

UniProtKB/TrEMBL

Q3TZU7, Q3U1P2

Related

ENSMUSP00000002436.10, ENSMUST00000002436.11

Conserved Domains (3) summary

cd07285
Location:250 → 375

PX_SNX9; The phosphoinositide binding Phox Homology domain of Sorting Nexin 9

cd07668
Location:386 → 595

BAR_SNX9; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9

cd11898
Location:4 → 60

SH3_SNX9; Src Homology 3 domain of Sorting nexin 9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

5891599..5982231

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017317612.3 → XP_017173101.1 sorting nexin-9 isoform X1

UniProtKB/TrEMBL

Q3TZU7

Conserved Domains (4) summary

cd07285
Location:250 → 375

PX_SNX9; The phosphoinositide binding Phox Homology domain of Sorting Nexin 9

cd07668
Location:386 → 595

BAR_SNX9; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9

cd11898
Location:5 → 60

SH3_SNX9; Src Homology 3 domain of Sorting nexin 9

COG5391
Location:127 → 357

COG5391; Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only]
XM_030249990.2 → XP_030105850.1 sorting nexin-9 isoform X2

UniProtKB/TrEMBL

Q9CZK0

Conserved Domains (2) summary

cd07285
Location:50 → 175

PX_SNX9; The phosphoinositide binding Phox Homology domain of Sorting Nexin 9

cd07668
Location:186 → 395

BAR_SNX9; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9