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    Ulk2 unc-51 like kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 29869, updated on 13-Jan-2025

    Summary

    Official Symbol
    Ulk2provided by MGI
    Official Full Name
    unc-51 like kinase 2provided by MGI
    Primary source
    MGI:MGI:1352758
    See related
    Ensembl:ENSMUSG00000004798 AllianceGenome:MGI:1352758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Unc51.2; mKIAA0623; A830085I22Rik
    Summary
    Enables protein serine/threonine kinase activity. Involved in autophagy and response to starvation. Acts upstream of or within several processes, including axonogenesis; negative regulation of collateral sprouting; and somatic sensory system development. Located in phagophore assembly site membrane. Is expressed in facial bone primordium; nervous system; and sensory organ. Orthologous to human ULK2 (unc-51 like autophagy activating kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 33.4), CNS E18 (RPKM 21.5) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Ulk2 in Genome Data Viewer
    Location:
    11 B2; 11 37.96 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61666424..61750754, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61775598..61855334, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 10 Neighboring gene family with sequence similarity 83, member G Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 2 Neighboring gene STARR-seq mESC enhancer starr_29688 Neighboring gene A kinase anchor protein 10 Neighboring gene STARR-seq mESC enhancer starr_29689 Neighboring gene STARR-positive B cell enhancer ABC_E8413 Neighboring gene predicted gene, 23721

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 26
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables protein binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in autophagosome assembly  
    involved_in autophagy PubMed 
    involved_in autophagy  
    involved_in axon extension  
    acts_upstream_of_or_within axon extension PubMed 
    acts_upstream_of_or_within axon guidance PubMed 
    involved_in chromatin remodeling  
    acts_upstream_of collateral sprouting PubMed 
    involved_in mitophagy  
    involved_in negative regulation of collateral sprouting  
    acts_upstream_of_or_within negative regulation of collateral sprouting PubMed 
    involved_in piecemeal microautophagy of the nucleus  
    involved_in protein autophosphorylation  
    acts_upstream_of_or_within protein localization PubMed 
    involved_in regulation of autophagy  
    involved_in regulation of autophagy  
    involved_in response to starvation  
    involved_in response to starvation PubMed 
    involved_in reticulophagy  
    involved_in signal transduction  
    acts_upstream_of_or_within somatic sensory system development PubMed 
    Component Evidence Code Pubs
    is_active_in autophagosome  
    is_active_in cytoplasm  
    located_in cytoplasmic vesicle membrane  
    is_active_in cytosol  
    is_active_in phagophore assembly site  
    is_active_in phagophore assembly site membrane  
    located_in phagophore assembly site membrane PubMed 
    located_in phagophore assembly site membrane  

    General protein information

    Preferred Names
    serine/threonine-protein kinase ULK2
    Names
    serine/threonine-protein kinase Unc51.2
    NP_038909.3
    XP_006533571.1
    XP_006533572.1
    XP_030101926.1
    XP_036012644.1
    XP_036012645.1
    XP_036012646.1
    XP_036012647.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013881.4NP_038909.3  serine/threonine-protein kinase ULK2

      See identical proteins and their annotated locations for NP_038909.3

      Status: VALIDATED

      Source sequence(s)
      AK146620, AK148142, AV256860, BM124275
      Consensus CDS
      CCDS24820.1
      UniProtKB/Swiss-Prot
      Q80TV7, Q9QY01, Q9WTP4
      UniProtKB/TrEMBL
      Q3UG39
      Related
      ENSMUSP00000004920.4, ENSMUST00000004920.4
      Conserved Domains (3) summary
      smart00220
      Location:9271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14201
      Location:2272
      STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
      pfam12063
      Location:8651030
      DUF3543; Domain of unknown function (DUF3543)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      61666424..61750754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156753.1XP_036012646.1  serine/threonine-protein kinase ULK2 isoform X6

      UniProtKB/TrEMBL
      Q3UG39
      Conserved Domains (2) summary
      pfam12063
      Location:725912
      DUF3543; Domain of unknown function (DUF3543)
      cl21453
      Location:1154
      PKc_like; Protein Kinases, catalytic domain
    2. XM_036156752.1XP_036012645.1  serine/threonine-protein kinase ULK2 isoform X5

      UniProtKB/TrEMBL
      Q3UG39
      Conserved Domains (2) summary
      pfam12063
      Location:725904
      DUF3543; Domain of unknown function (DUF3543)
      cl21453
      Location:1154
      PKc_like; Protein Kinases, catalytic domain
    3. XM_036156751.1XP_036012644.1  serine/threonine-protein kinase ULK2 isoform X2

      UniProtKB/TrEMBL
      Q3UG39
      Conserved Domains (2) summary
      pfam12063
      Location:809988
      DUF3543; Domain of unknown function (DUF3543)
      cl21453
      Location:2238
      PKc_like; Protein Kinases, catalytic domain
    4. XM_030246066.2XP_030101926.1  serine/threonine-protein kinase ULK2 isoform X4

      UniProtKB/TrEMBL
      Q3UG39
      Conserved Domains (2) summary
      cd14201
      Location:2272
      STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
      pfam12063
      Location:802984
      DUF3543; Domain of unknown function (DUF3543)
    5. XM_006533509.5XP_006533572.1  serine/threonine-protein kinase ULK2 isoform X3

      UniProtKB/TrEMBL
      Q3UG39
      Conserved Domains (2) summary
      cd14201
      Location:2272
      STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
      pfam12063
      Location:802973
      DUF3543; Domain of unknown function (DUF3543)
    6. XM_036156754.1XP_036012647.1  serine/threonine-protein kinase ULK2 isoform X7

      Conserved Domains (1) summary
      pfam12063
      Location:367546
      DUF3543; Domain of unknown function (DUF3543)
    7. XM_006533508.5XP_006533571.1  serine/threonine-protein kinase ULK2 isoform X1

      UniProtKB/TrEMBL
      Q3UG39
      Conserved Domains (2) summary
      cd14201
      Location:2272
      STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
      pfam12063
      Location:8481019
      DUF3543; Domain of unknown function (DUF3543)
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