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    Mplkip M-phase specific PLK1 interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684996, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mplkipprovided by RGD
    Official Full Name
    M-phase specific PLK1 interacting proteinprovided by RGD
    Primary source
    RGD:1584365
    See related
    EnsemblRapid:ENSRNOG00000013806 AllianceGenome:RGD:1584365
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in centrosome; midbody; and nucleus. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 4. Orthologous to human MPLKIP (M-phase specific PLK1 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 125.4), Testes (RPKM 97.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mplkip in Genome Data Viewer
    Location:
    17q11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (52069154..52071978, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (47373624..47376199, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (49955060..49990982, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene phosphoglycerate mutase 1, pseudogene 5 Neighboring gene cyclin-dependent kinase 13 Neighboring gene succinylCoA:glutarate-CoA transferase Neighboring gene macrophage migration inhibitory factor, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity. Zhang Y, et al. Cell Mol Life Sci, 2007 Mar. PMID 17310276, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    M-phase-specific PLK1-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109452.1 → NP_001102922.1  M-phase-specific PLK1-interacting protein

      See identical proteins and their annotated locations for NP_001102922.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474030
      UniProtKB/TrEMBL
      A6K9A5, D3ZR59, D3ZVR4
      Related
      ENSRNOP00000068955.1, ENSRNOT00000080628.3
      Conserved Domains (1) summary
      pfam15502
      Location:122 → 178
      MPLKIP; M-phase-specific PLK1-interacting protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      52069154..52071978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096069.2 → XP_038951997.1  M-phase-specific PLK1-interacting protein isoform X1

      UniProtKB/TrEMBL
      A6K9A5, D3ZR59, D3ZVR4
      Conserved Domains (1) summary
      pfam15502
      Location:122 → 178
      MPLKIP; M-phase-specific PLK1-interacting protein
    Nucleotide Protein Strain
    Heading Accession and Version

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