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    Axdnd1 axonemal dynein light chain domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 77352, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Axdnd1provided by MGI
    Official Full Name
    axonemal dynein light chain domain containing 1provided by MGI
    Primary source
    MGI:MGI:1924602
    See related
    Ensembl:ENSMUSG00000026601 AllianceGenome:MGI:1924602
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm979; 9430070O13Rik
    Summary
    Involved in manchette assembly. Located in cytoplasm. Orthologous to human AXDND1 (axonemal dynein light chain domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 15.3) See more
    Orthologs
    human all
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    Genomic context

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    See Axdnd1 in Genome Data Viewer
    Location:
    1 G3; 1 67.71 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (156157985..156248743, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (156330415..156421176, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:158194711-158194894 Neighboring gene STARR-seq mESC enhancer starr_02735 Neighboring gene tudor domain containing 5 Neighboring gene nephrosis 2, podocin Neighboring gene ribosomal protein L35, retrotransposed Neighboring gene STARR-seq mESC enhancer starr_02736 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:158338195-158338508 Neighboring gene STARR-positive B cell enhancer ABC_E3317 Neighboring gene STARR-positive B cell enhancer ABC_E9485 Neighboring gene sterol O-acyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E2571 Neighboring gene STARR-positive B cell enhancer mm9_chr1:158404407-158404707 Neighboring gene predicted gene, 39682

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of Axdnd1 causes sterility due to impaired spermatid differentiation in mice. Hiradate Y, et al. Reprod Med Biol, 2022 Jan-Dec. PMID 35386379, Free PMC Article
    2. AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans. Houston BJ, et al. Cell Death Dis, 2024 Jul 12. PMID 38997255, Free PMC Article
    3. AXDND1, a novel testis-enriched gene, is required for spermiogenesis and male fertility. Ma Q, et al. Cell Death Discov, 2021 Nov 11. PMID 34759295, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans.
      Title: AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in manchette assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    axonemal dynein light chain domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346967.1 → NP_001333896.1  axonemal dynein light chain domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      AC161221, AC161414
      Consensus CDS
      CCDS83611.1
      UniProtKB/Swiss-Prot
      A0A1D5RLL5, Q3UZ57
      UniProtKB/TrEMBL
      J3QPL7
      Related
      ENSMUSP00000148420.2, ENSMUST00000213088.3
      Conserved Domains (1) summary
      pfam10211
      Location:209 → 364
      Ax_dynein_light; Axonemal dynein light chain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      156157985..156248743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243577.2 → XP_030099437.1  axonemal dynein light chain domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A0A1D5RLL5, Q3UZ57
      UniProtKB/TrEMBL
      J3QPL7
      Related
      ENSMUSP00000137354.2, ENSMUST00000178036.8
      Conserved Domains (1) summary
      pfam10211
      Location:209 → 364
      Ax_dynein_light; Axonemal dynein light chain

    2. XM_030243584.2 → XP_030099444.1  axonemal dynein light chain domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      J3QPL7
      Related
      ENSMUSP00000135900.2, ENSMUST00000177824.8
      Conserved Domains (1) summary
      pfam10211
      Location:168 → 323
      Ax_dynein_light; Axonemal dynein light chain

    3. XM_036154380.1 → XP_036010273.1  axonemal dynein light chain domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      J3KMJ8
      Conserved Domains (1) summary
      pfam10211
      Location:101 → 207
      Ax_dynein_light; Axonemal dynein light chain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033180.2: Suppressed sequence

      Description
      NM_001033180.2: This RefSeq was temporarily suppressed because the CDS was partial.

    2. NM_001198597.1: Suppressed sequence

      Description
      NM_001198597.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UZ57.2 GenPept UniProtKB/Swiss-Prot:Q3UZ57

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials