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    Septin10 septin 10 [ Mus musculus (house mouse) ]

    Gene ID: 103080, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Septin10provided by MGI
    Official Full Name
    septin 10provided by MGI
    Primary source
    MGI:MGI:1918110
    See related
    Ensembl:ENSMUSG00000019917 AllianceGenome:MGI:1918110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sept10; 4921515A04Rik; 9430099J10Rik
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis and protein localization. Located in sperm annulus. Is expressed in brain; cochlea; and testis. Orthologous to human SEPTIN10 (septin 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 14.3), bladder adult (RPKM 8.0) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Septin10 in Genome Data Viewer
    Location:
    10 B4; 10 29.48 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (58977446..59057322, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (59141624..59221500, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26764 Neighboring gene zinc finger CCCH type containing 11A pseudogene Neighboring gene SH3 domain containing ring finger 3 Neighboring gene STARR-seq mESC enhancer starr_26766 Neighboring gene predicted gene, 53588 Neighboring gene STARR-positive B cell enhancer ABC_E6855 Neighboring gene predicted gene, 23223 Neighboring gene sosondowah ankyrin repeat domain family member C Neighboring gene predicted gene, 36257 Neighboring gene predicted gene, 40669

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Localization of septin proteins in the mouse cochlea. Yoshida A, et al. Hear Res, 2012 Jul. PMID 22575789, Free PMC Article
    2. Androglobin, a chimeric mammalian globin, is required for male fertility. Keppner A, et al. Elife, 2022 Jun 14. PMID 35700329, Free PMC Article
    3. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
    4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm annulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    septin-10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024910.4 → NP_001020081.2  septin-10 isoform 1

      See identical proteins and their annotated locations for NP_001020081.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC153941, AC159909
      Consensus CDS
      CCDS88009.1
      UniProtKB/Swiss-Prot
      Q7TSA5, Q8C650
      UniProtKB/TrEMBL
      A0A1W2P6J7
      Related
      ENSMUSP00000151293.2, ENSMUST00000220156.2
      Conserved Domains (3) summary
      cd01850
      Location:36 → 304
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:17 → 389
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cl20817
      Location:333 → 389
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. NM_001024911.3 → NP_001020082.1  septin-10 isoform 2

      See identical proteins and their annotated locations for NP_001020082.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 3' coding region and 3' UTR, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC153941
      Consensus CDS
      CCDS48566.1
      UniProtKB/Swiss-Prot
      Q7TSA5, Q8C650
      UniProtKB/TrEMBL
      A0A0R4J233
      Related
      ENSMUSP00000129023.2, ENSMUST00000165971.3
      Conserved Domains (3) summary
      cd01850
      Location:36 → 304
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:17 → 389
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cl20817
      Location:333 → 389
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. NM_001379063.1 → NP_001365992.1  septin-10 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AC153941, AC159909
      UniProtKB/Swiss-Prot
      Q7TSA5, Q8C650
      Conserved Domains (2) summary
      PTZ00121
      Location:274 → 426
      PTZ00121; MAEBL; Provisional
      cd01850
      Location:40 → 308
      CDC_Septin; CDC/Septin GTPase family

    4. NM_001379064.1 → NP_001365993.1  septin-10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153941
      UniProtKB/Swiss-Prot
      Q7TSA5, Q8C650
      Conserved Domains (2) summary
      cd01850
      Location:40 → 308
      CDC_Septin; CDC/Septin GTPase family
      COG3064
      Location:322 → 405
      TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]

    5. NM_001379065.1 → NP_001365994.1  septin-10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153941
      UniProtKB/Swiss-Prot
      Q7TSA5, Q8C650
      Conserved Domains (2) summary
      cd01850
      Location:40 → 308
      CDC_Septin; CDC/Septin GTPase family
      COG3064
      Location:322 → 405
      TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]

    6. NM_001379066.1 → NP_001365995.1  septin-10 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC153941
      UniProtKB/Swiss-Prot
      Q7TSA5, Q8C650
      Conserved Domains (2) summary
      cd01850
      Location:36 → 304
      CDC_Septin; CDC/Septin GTPase family
      COG3064
      Location:318 → 401
      TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]

    RNA

    1. NR_166449.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153941

    2. NR_166450.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153941

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      58977446..59057322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C650.1 GenPept UniProtKB/Swiss-Prot:Q8C650

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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