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    C2cd4c C2 calcium-dependent domain containing 4C [ Mus musculus (house mouse) ]

    Gene ID: 237397, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C2cd4cprovided by MGI
    Official Full Name
    C2 calcium-dependent domain containing 4Cprovided by MGI
    Primary source
    MGI:MGI:2685084
    See related
    Ensembl:ENSMUSG00000045912 AllianceGenome:MGI:2685084
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm238; Fam148c; 4932409I22Rik
    Summary
    Is active in cytosol. Is expressed in several structures, including pancreas. Orthologous to human C2CD4C (C2 calcium dependent domain containing 4C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 2.9), cortex adult (RPKM 1.9) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See C2cd4c in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79442688..79449859, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79606854..79614025, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene MIER family member 2 Neighboring gene sperm microtubule associated protein 2 Neighboring gene predicted gene, 51808 Neighboring gene SHC (Src homology 2 domain containing) transforming protein 2 Neighboring gene CIMAP1 family member D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development. Omori H, et al. FEBS Lett, 2016 Aug. PMID 27349930, Free PMC Article
    2. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our results suggest that C2cd4c is dispensable for pancreatic development.
      Title: Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC86088

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C2 calcium-dependent domain-containing protein 4C
    Names
    C2cd4cC2CD4 family
    family with sequence similarity 148, member C
    nuclear-localized factor 3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168624.1 → NP_001162095.1  C2 calcium-dependent domain-containing protein 4C

      See identical proteins and their annotated locations for NP_001162095.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK029946, BC089008
      Consensus CDS
      CCDS23979.1
      UniProtKB/Swiss-Prot
      Q5HZI2, Q8CDK0
      Related
      ENSMUSP00000136013.2, ENSMUST00000178228.3
      Conserved Domains (1) summary
      smart00239
      Location:319 → 416
      C2; Protein kinase C conserved region 2 (CalB)

    2. NM_198614.3 → NP_941016.2  C2 calcium-dependent domain-containing protein 4C

      See identical proteins and their annotated locations for NP_941016.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC089008, BY268666
      Consensus CDS
      CCDS23979.1
      UniProtKB/Swiss-Prot
      Q5HZI2, Q8CDK0
      Related
      ENSMUSP00000059433.8, ENSMUST00000059699.9
      Conserved Domains (1) summary
      smart00239
      Location:319 → 416
      C2; Protein kinase C conserved region 2 (CalB)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79442688..79449859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HZI2.1 GenPept UniProtKB/Swiss-Prot:Q5HZI2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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