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    4931414P19Rik RIKEN cDNA 4931414P19 gene [ Mus musculus (house mouse) ]

    Gene ID: 74359, updated on 27-Nov-2024

    Summary

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    Official Symbol
    4931414P19Rikprovided by MGI
    Official Full Name
    RIKEN cDNA 4931414P19 geneprovided by MGI
    Primary source
    MGI:MGI:1921609
    See related
    Ensembl:ENSMUSG00000022179 AllianceGenome:MGI:1921609
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rtfc
    Summary
    Acts upstream of or within cell differentiation and positive regulation of gene expression. Predicted to be located in extracellular region. Orthologous to human C14orf93 (chromosome 14 open reading frame 93). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 1.6), limb E14.5 (RPKM 1.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See 4931414P19Rik in Genome Data Viewer
    Location:
    14 C2; 14 27.85 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54821119..54843450, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54583662..54606099, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36740 Neighboring gene ajuba LIM protein Neighboring gene STARR-seq mESC enhancer starr_36741 Neighboring gene STARR-positive B cell enhancer ABC_E7313 Neighboring gene U6 small nuclear RNA, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_36743 Neighboring gene STARR-positive B cell enhancer ABC_E7314 Neighboring gene STARR-positive B cell enhancer mm9_chr14:55236824-55237125 Neighboring gene proteasome (prosome, macropain) subunit, beta type 5 Neighboring gene microRNA 686 Neighboring gene proteasome (prosome, macropain) subunit, beta type, 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. 4931414P19Rik, a microglia chemoattractant secreted by neural progenitors, modulates neuronal migration during corticogenesis. Mestres I, et al. Development, 2023 May 1. PMID 37070770, Free PMC Article
    2. Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function. Yu Y, et al. Sci Rep, 2017 Feb 23. PMID 28230092, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rtfc (4931414P19Rik) regulates in vitro thyroid differentiation and in vivo thyroid function.
      Title: Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein C14orf93 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028890.2 → NP_083166.1  uncharacterized protein C14orf93 homolog precursor

      See identical proteins and their annotated locations for NP_083166.1

      Status: PROVISIONAL

      Source sequence(s)
      CT009512
      Consensus CDS
      CCDS27094.1
      UniProtKB/Swiss-Prot
      Q8K2W9
      Related
      ENSMUSP00000022786.5, ENSMUST00000022786.6
      Conserved Domains (1) summary
      pfam15394
      Location:2 → 538
      DUF4616; Domain of unknown function (DUF4616)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      54821119..54843450 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158880.1 → XP_036014773.1  uncharacterized protein C14orf93 homolog isoform X2

      Conserved Domains (1) summary
      pfam15394
      Location:2 → 432
      DUF4616; Domain of unknown function (DUF4616)

    2. XM_006519618.5 → XP_006519681.1  uncharacterized protein C14orf93 homolog isoform X1

      See identical proteins and their annotated locations for XP_006519681.1

      UniProtKB/Swiss-Prot
      Q8K2W9
      Conserved Domains (1) summary
      pfam15394
      Location:2 → 538
      DUF4616; Domain of unknown function (DUF4616)

    3. XM_036158879.1 → XP_036014772.1  uncharacterized protein C14orf93 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8K2W9
      Conserved Domains (1) summary
      pfam15394
      Location:2 → 538
      DUF4616; Domain of unknown function (DUF4616)

    4. XM_011245210.4 → XP_011243512.1  uncharacterized protein C14orf93 homolog isoform X1

      See identical proteins and their annotated locations for XP_011243512.1

      UniProtKB/Swiss-Prot
      Q8K2W9
      Conserved Domains (1) summary
      pfam15394
      Location:2 → 538
      DUF4616; Domain of unknown function (DUF4616)

    5. XM_006519620.5 → XP_006519683.1  uncharacterized protein C14orf93 homolog isoform X1

      See identical proteins and their annotated locations for XP_006519683.1

      UniProtKB/Swiss-Prot
      Q8K2W9
      Conserved Domains (1) summary
      pfam15394
      Location:2 → 538
      DUF4616; Domain of unknown function (DUF4616)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2W9.1 GenPept UniProtKB/Swiss-Prot:Q8K2W9

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