Cideb cell death-inducing DNA fragmentation factor, alpha subunit-like effector B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cidebprovided by MGI
Official Full Name: cell death-inducing DNA fragmentation factor, alpha subunit-like effector Bprovided by MGI
Primary source: MGI:MGI:1270844
See related: Ensembl:ENSMUSG00000022219 AllianceGenome:MGI:1270844
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CIDE-B; 1110030C18Rik
Summary: Enables lipid transfer activity; molecular adaptor activity; and phosphatidic acid binding activity. Involved in several processes, including COPII-coated vesicle cargo loading; lipid droplet fusion; and very-low-density lipoprotein particle assembly. Part of COPII vesicle coat. Is active in Golgi apparatus; endoplasmic reticulum membrane; and lipid droplet. Is expressed in autopod; dorsal root ganglion; and urinary system. Orthologous to human CIDEB (cell death inducing DFFA like effector b). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in small intestine adult (RPKM 216.9), liver adult (RPKM 205.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (55991509..55995881, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (55754052..55758424, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High Cideb expression is associated with Ulcerative Colitis.
Title: Cideb Deficiency Aggravates Dextran Sulfate Sodium-induced Ulcerative Colitis in Mice by Exacerbating the Oxidative Burden in Colonic Mucosa.
these data revealed that Cideb plays an important role in controlling intestinal chylomicron lipidation.
Title: Cideb facilitates the lipidation of chylomicrons in the small intestine.
Data (including data from studies in knockout mice) suggest Cideb promotes lipid storage as droplets in hepatocytes under normal diet conditions; Cidea/Cidec promote fusion of lipid droplets leading to liver steatosis in fasting (16h) and obese mice.
Title: Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes.
Cideb and perilipin 2 play opposing roles in controlling VLDL lipidation and hepatic lipid homeostasis
Title: Opposing roles of cell death-inducing DFF45-like effector B and perilipin 2 in controlling hepatic VLDL lipidation.
SREBP-1c mediates the effect of insulin on the expression of Cidea in mouse hepatocytes.
Title: Sterol-regulatory-element-binding protein 1c mediates the effect of insulin on the expression of Cidea in mouse hepatocytes.
Data suggest that Cideb is a novel regulator in controlling cholesterol homeostasis in the liver.
Title: Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb.
Cideb protein promotes the formation of triacylglycerol-enriched VLDL particles and provides a molecular insight into VLDL lipidation and maturation in hepatocytes.
Title: Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B.
Cideb is a novel important regulator in lipid metabolism in the liver and may thus represent a new therapeutic target for the treatment of obesity, diabetes, and liver steatosis
Title: Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidic acid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in COPII-coated vesicle cargo loading	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in execution phase of apoptosis	IDA Inferred from Direct Assay more info	PubMed
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in lipid droplet fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid droplet fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid droplet fusion	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of triglyceride metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in very-low-density lipoprotein particle assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in COPI-coated vesicle	IEA Inferred from Electronic Annotation more info
part_of COPII vesicle coat	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
is_active_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lipid transferase CIDEB

Names: DFFA-like B; cell death activator CIDE-B; cell death-inducing DFFA-like effector B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009894.3 → NP_034024.2 lipid transferase CIDEB

See identical proteins and their annotated locations for NP_034024.2

Status: VALIDATED

Source sequence(s)

AK003968, BQ175754, CB600615

Consensus CDS

CCDS27127.1

UniProtKB/Swiss-Prot

O70303, Q91X39

Related

ENSMUSP00000001497.8, ENSMUST00000001497.9

Conserved Domains (1) summary

cd06537
Location:34 → 114

CIDE_N_B; CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

55991509..55995881 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_026804.1: Suppressed sequence

Description

NM_026804.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.