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    Akap11 A kinase anchor protein 11 [ Mus musculus (house mouse) ]

    Gene ID: 219181, updated on 9-Dec-2024

    Summary

    Official Symbol
    Akap11provided by MGI
    Official Full Name
    A kinase anchor protein 11provided by MGI
    Primary source
    MGI:MGI:2684060
    See related
    Ensembl:ENSMUSG00000022016 AllianceGenome:MGI:2684060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm80; PRKA11; AKAP220; mKIAA0629; 6330501D17Rik
    Summary
    Enables protein kinase A regulatory subunit binding activity. Acts upstream of or within cortical actin cytoskeleton organization; protein localization to endosome; and renal water homeostasis. Predicted to be located in several cellular components, including cytosol; nucleolus; and peroxisome. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; eye; genitourinary system; immune system; and nervous system. Orthologous to human AKAP11 (A-kinase anchoring protein 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 13.7), cortex adult (RPKM 12.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Akap11 in Genome Data Viewer
    Location:
    14 D3; 14 41.46 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (78729686..78774306, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (78492246..78536980, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:78831878-78832061 Neighboring gene predicted gene, 18277 Neighboring gene STARR-positive B cell enhancer mm9_chr14:78848555-78848856 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37228 Neighboring gene STARR-positive B cell enhancer ABC_E5460 Neighboring gene STARR-seq mESC enhancer starr_37230 Neighboring gene diacylglycerol kinase, eta Neighboring gene predicted gene, 26251 Neighboring gene predicted gene, 30716

    Genomic regions, transcripts, and products

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase A catalytic subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase A regulatory subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase 1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    A-kinase anchor protein 11
    Names
    A kinase (PRKA) anchor protein 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164503.1NP_001157975.1  A-kinase anchor protein 11 isoform 1

      See identical proteins and their annotated locations for NP_001157975.1

      Status: VALIDATED

      Source sequence(s)
      AC161608, AK032821, AK158300, AK164604
      Consensus CDS
      CCDS49549.1
      UniProtKB/TrEMBL
      E9Q777
      Related
      ENSMUSP00000116015.3, ENSMUST00000123853.9
      Conserved Domains (1) summary
      cl14906
      Location:18081883
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    2. NM_001346784.1NP_001333713.1  A-kinase anchor protein 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161608
      Consensus CDS
      CCDS84155.1
      UniProtKB/TrEMBL
      E9Q777
      Conserved Domains (1) summary
      cl14906
      Location:18091884
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      78729686..78774306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158570.1XP_036014463.1  A-kinase anchor protein 11 isoform X3

      Conserved Domains (1) summary
      cl14906
      Location:16381855
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    2. XM_030247770.2XP_030103630.1  A-kinase anchor protein 11 isoform X1

      Conserved Domains (1) summary
      cl14906
      Location:18091884
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    3. XM_030247771.2XP_030103631.1  A-kinase anchor protein 11 isoform X2

      Conserved Domains (1) summary
      cl14906
      Location:18011876
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)