Ostn osteocrin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ostnprovided by MGI
Official Full Name: osteocrinprovided by MGI
Primary source: MGI:MGI:2677164
See related: Ensembl:ENSMUSG00000052276 AllianceGenome:MGI:2677164
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ostc
Summary: Enables signaling receptor binding activity. Acts upstream of or within several processes, including endochondral bone growth; negative regulation of D-glucose import; and negative regulation of osteoblast differentiation. Located in extracellular space. Is expressed in genitourinary system; heart; musculature; and skeleton. Orthologous to human OSTN (osteocrin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 16 B2; 16 18.88 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (27125733..27169959)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (27307641..27351209)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis.
Title: Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis.
The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice.
Title: The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice.
Mustn1 ablation in skeletal muscle results in increased glucose tolerance concomitant with upregulated GLUT expression in male mice.
Title: Mustn1 ablation in skeletal muscle results in increased glucose tolerance concomitant with upregulated GLUT expression in male mice.
Myokine Musclin Is Critical for Exercise-Induced Cardiac Conditioning.
Title: Myokine Musclin Is Critical for Exercise-Induced Cardiac Conditioning.
Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia-reperfusion injury in mice.
Title: Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia-reperfusion injury in mice.
Skeletal muscle derived Musclin protects the heart during pathological overload.
Title: Skeletal muscle derived Musclin protects the heart during pathological overload.
Mechanical load regulates bone growth via periosteal Osteocrin.
Title: Mechanical load regulates bone growth via periosteal Osteocrin.
Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition.
Title: Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition.
Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.
Title: Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.
The mechanism underlying the effect of OSTN on skeletal growth relevant to C-type natriuretic peptide /Natriuretic peptide receptor B signaling.
Title: Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within endochondral bone growth	IDA Inferred from Direct Assay more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hormone-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of D-glucose import	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of dendrite extension	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of bone mineralization	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: osteocrin

Names: musclin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198112.2 → NP_932780.1 osteocrin precursor

See identical proteins and their annotated locations for NP_932780.1

Status: PROVISIONAL

Source sequence(s)

AC154512

Consensus CDS

CCDS28090.1

UniProtKB/Swiss-Prot

P61364, Q149W1

Related

ENSMUSP00000067539.9, ENSMUST00000066852.9

Conserved Domains (1) summary

pfam11037
Location:2 → 130

Musclin; Insulin-resistance promoting peptide in skeletal muscle

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

27125733..27169959

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159921.1 → XP_036015814.1 osteocrin isoform X1

UniProtKB/Swiss-Prot

P61364, Q149W1

Conserved Domains (1) summary

pfam11037
Location:2 → 130

Musclin; Insulin-resistance promoting peptide in skeletal muscle