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    Spindoc spindlin interactor and repressor of chromatin binding [ Mus musculus (house mouse) ]

    Gene ID: 68229, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Spindocprovided by MGI
    Official Full Name
    spindlin interactor and repressor of chromatin bindingprovided by MGI
    Primary source
    MGI:MGI:2147611
    See related
    Ensembl:ENSMUSG00000024970 AllianceGenome:MGI:2147611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPIN-DOC; 1700105P06Rik
    Summary
    Involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus and site of DNA damage. Orthologous to human SPINDOC (spindlin interactor and repressor of chromatin binding). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 16.5), thymus adult (RPKM 10.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Spindoc in Genome Data Viewer
    Location:
    19 A; 19 5.32 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7333828..7364491, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7356463..7384302, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene REST corepressor 2 Neighboring gene MAP/microtubule affinity regulating kinase 2 Neighboring gene predicted gene 17227 Neighboring gene STARR-seq mESC enhancer starr_45463 Neighboring gene STARR-seq mESC enhancer starr_45464 Neighboring gene STARR-seq mESC enhancer starr_45465 Neighboring gene RIKEN cDNA 1700105P06 gene Neighboring gene STARR-positive B cell enhancer ABC_E3240 Neighboring gene RAB11B, member RAS oncogene family, pseudogene 2 Neighboring gene predicted gene, 18842

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Spin1 interactor, Spindoc, is dispensable for meiotic division, but essential for haploid spermatid development in mice. Jiang X, et al. Reprod Biol Endocrinol, 2021 Sep 15. PMID 34526015, Free PMC Article
    2. SPINDOC binds PARP1 to facilitate PARylation. Yang F, et al. Nat Commun, 2021 Nov 4. PMID 34737271, Free PMC Article
    3. A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1. Bae N, et al. J Biol Chem, 2017 Dec 22. PMID 29061846, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Spin1 interactor, Spindoc, is dispensable for meiotic division, but essential for haploid spermatid development in mice.
      Title: The Spin1 interactor, Spindoc, is dispensable for meiotic division, but essential for haploid spermatid development in mice.
    2. SPINDOC binds PARP1 to facilitate PARylation.
      Title: SPINDOC binds PARP1 to facilitate PARylation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein ADP-ribosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of DNA damage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    spindlin interactor and repressor of chromatin-binding protein
    Names
    SPIN1-docking protein
    uncharacterized protein C11orf84 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033139.4 → NP_001028311.2  spindlin interactor and repressor of chromatin-binding protein isoform 1

      See identical proteins and their annotated locations for NP_001028311.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC129188
      Consensus CDS
      CCDS29523.1
      UniProtKB/Swiss-Prot
      Q05AH6, Q3TI49, Q3TQH2
      Related
      ENSMUSP00000025924.3, ENSMUST00000025924.4

    2. NM_001167831.2 → NP_001161303.1  spindlin interactor and repressor of chromatin-binding protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC129188
      UniProtKB/TrEMBL
      A0A494BBB2
      Related
      ENSMUST00000236817.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      7333828..7364491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251065.2 → XP_030106925.1  spindlin interactor and repressor of chromatin-binding protein isoform X3

      Conserved Domains (1) summary
      pfam18658
      Location:71 → 135
      zf-C2H2_12; Zinc-finger C2H2-type

    2. XM_011247332.4 → XP_011245634.1  spindlin interactor and repressor of chromatin-binding protein isoform X2

      Conserved Domains (1) summary
      pfam18658
      Location:110 → 174
      zf-C2H2_12; Zinc-finger C2H2-type

    3. XM_011247331.4 → XP_011245633.1  spindlin interactor and repressor of chromatin-binding protein isoform X1

      Conserved Domains (1) summary
      pfam18658
      Location:110 → 174
      zf-C2H2_12; Zinc-finger C2H2-type

    RNA

    1. XR_003952811.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05AH6.1 GenPept UniProtKB/Swiss-Prot:Q05AH6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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