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    Tmigd3 transmembrane and immunoglobulin domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 69296, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmigd3provided by MGI
    Official Full Name
    transmembrane and immunoglobulin domain containing 3provided by MGI
    Primary source
    MGI:MGI:5604098
    See related
    Ensembl:ENSMUSG00000000562 Ensembl:ENSMUSG00000074344 AllianceGenome:MGI:5604098
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700001d09rik; 4930578J19Rik; Tg(H2-K-CALR*)del52Shmd
    Summary
    This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 3' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:11542). [provided by RefSeq, Nov 2014]
    Expression
    Restricted expression toward testis adult (RPKM 42.0) See more
    Orthologs
    human all
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    Genomic context

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    See Tmigd3 in Genome Data Viewer
    Location:
    3 F2.2; 3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (105778174..105831360)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (105870858..105924044)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RAS-related protein 1a Neighboring gene STARR-positive B cell enhancer ABC_E10203 Neighboring gene STARR-positive B cell enhancer ABC_E11208 Neighboring gene STARR-seq mESC enhancer starr_08637 Neighboring gene predicted gene 5547 Neighboring gene STARR-seq mESC enhancer starr_08638 Neighboring gene STARR-seq mESC enhancer starr_08639 Neighboring gene STARR-positive B cell enhancer ABC_E9566 Neighboring gene STARR-positive B cell enhancer ABC_E9567 Neighboring gene RIKEN cDNA I830077J02 gene Neighboring gene adenosine A3 receptor Neighboring gene STARR-seq mESC enhancer starr_08641 Neighboring gene ATP synthase peripheral stalk-membrane subunit b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Calreticulin haploinsufficiency augments stem cell activity and is required for onset of myeloproliferative neoplasms in mice. Shide K, et al. Blood, 2020 Jul 2. PMID 32219445, Free PMC Article
    2. Calreticulin mutant mice develop essential thrombocythemia that is ameliorated by the JAK inhibitor ruxolitinib. Shide K, et al. Leukemia, 2017 May. PMID 27807369, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response-activating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane domain-containing protein TMIGD3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001174169.2 → NP_001167640.1  transmembrane domain-containing protein TMIGD3 isoform 3

      See identical proteins and their annotated locations for NP_001167640.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes the same 5' terminal exon but lacks the remaining exons and instead includes an alternate 3' terminal exon, compared to variant 2. The 3' terminal exon is shared with that of the adenosine A3 receptor gene. The encoded isoform (3), which is shorter and distinct compared to isoform 2, represents the C-terminal region of the adenosine A3 receptor.
      Source sequence(s)
      AC121847, BC100416
      Consensus CDS
      CCDS51036.1
      UniProtKB/TrEMBL
      Q497R5
      Related
      ENSMUSP00000126710.2, ENSMUST00000164730.2
      Conserved Domains (1) summary
      pfam00001
      Location:1 → 137
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. NM_027025.4 → NP_081301.2  transmembrane domain-containing protein TMIGD3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_081301.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longer isoform (2), which is a transmembrane and immunoglobulin domain-containing protein and it does not share any similarity with the adenosine A3 receptor.
      Source sequence(s)
      AC121847, AK005581, BC038878
      Consensus CDS
      CCDS38582.1
      UniProtKB/Swiss-Prot
      G3X8R9, Q9DAR9
      UniProtKB/TrEMBL
      A0A0G2JE84
      Related
      ENSMUSP00000010279.5, ENSMUST00000010279.10
      Conserved Domains (1) summary
      cl11960
      Location:24 → 105
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      105778174..105831360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3X8R9.1 GenPept UniProtKB/Swiss-Prot:G3X8R9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials