Clec4b1 C-type lectin domain family 4, member b1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec4b1provided by MGI
Official Full Name: C-type lectin domain family 4, member b1provided by MGI
Primary source: MGI:MGI:1917060
See related: Ensembl:ENSMUSG00000030147 AllianceGenome:MGI:1917060
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DCAR; Dcar2; Aplra2; Clec4b; DCARbeta; 1810046I24Rik
Summary: Predicted to enable carbohydrate binding activity and pattern recognition receptor activity. Acts upstream of or within positive regulation of release of sequestered calcium ion into cytosol. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC4C (C-type lectin domain family 4 member C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in mammary gland adult (RPKM 2.4), subcutaneous fat pad adult (RPKM 1.6) and 9 other tissues See more
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Genomic context

Location:: 6 F2; 6 58.13 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (123026921..123048514)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (123049962..123071555)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors.
Title: Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors.
Structural insight into the recognition of pathogen-derived phosphoglycolipids by C-type lectin receptor DCAR.
Title: Structural insight into the recognition of pathogen-derived phosphoglycolipids by C-type lectin receptor DCAR.
Identification of Clec4b as a novel regulator of bystander activation of auto-reactive T cells and autoimmune disease.
Title: Identification of Clec4b as a novel regulator of bystander activation of auto-reactive T cells and autoimmune disease.
DCAR is a critical receptor for phosphatidyl-inositol mannosides that functions to promote T cell responses against mycobacteria
Title: C-Type Lectin Receptor DCAR Recognizes Mycobacterial Phosphatidyl-Inositol Mannosides to Promote a Th1 Response during Infection.
While DCIR1 was ubiquitously expressed on myeloid cells in various immune organs, significant expression of DCAR2 was detected only on subpopulations of conventional dendritic cells from bone marrow and skin-draining lymph nodes.
Title: Ubiquitous versus restricted expression of the two mouse dendritic cell C-type lectin receptors, DCIR1 and DCAR2, among myeloid cells.
identifed a novel C-type lectin receptor, dendritic cell immunoactivating receptor (DCAR), whose extracellular lectin domain is highly homologous to that of dendritic cell immunoreceptor(DCIR) [DCAR]
Title: Dendritic cell immunoactivating receptor, a novel C-type lectin immunoreceptor, acts as an activating receptor through association with Fc receptor gamma chain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (2)

General gene information

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Markers

BE200183 (e-PCR)
- UniSTS:208028

D1S3699 (e-PCR)
- UniSTS:474277

NoName (e-PCR)
- UniSTS:485288

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antifungal innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of release of sequestered calcium ion into cytosol	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C-type lectin domain family 4, member b1

Names: antigen presenting cell lectin-like receptor A2; dendritic cell immunoactivating receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190310.1 → NP_001177239.1 C-type lectin domain family 4, member b1 isoform 1

See identical proteins and their annotated locations for NP_001177239.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC124337

Consensus CDS

CCDS51893.1

UniProtKB/TrEMBL

Q7TS58

Related

ENSMUSP00000077636.5, ENSMUST00000078559.5

Conserved Domains (1) summary

cd03590
Location:78 → 204

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
NM_027218.3 → NP_081494.1 C-type lectin domain family 4, member b1 isoform 2

See identical proteins and their annotated locations for NP_081494.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AA914236, AC124337, AK007794

Consensus CDS

CCDS39625.1

UniProtKB/TrEMBL

Q9D8Q7

Related

ENSMUSP00000076466.5, ENSMUST00000077228.11

Conserved Domains (1) summary

cd03590
Location:45 → 171

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)