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    Tsks testis-specific serine kinase substrate [ Mus musculus (house mouse) ]

    Gene ID: 22116, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tsksprovided by MGI
    Official Full Name
    testis-specific serine kinase substrateprovided by MGI
    Primary source
    MGI:MGI:1347560
    See related
    Ensembl:ENSMUSG00000059891 AllianceGenome:MGI:1347560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tssks1; Stk22s1
    Summary
    This gene is a member of a small family of testis-specific serine/threonine kinases. This gene may play a role in testicular physiology or spermiogenesis. Its expression is restricted to the testis during the last stages of spermatid maturation. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis adult (RPKM 199.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tsks in Genome Data Viewer
    Location:
    7 B3; 7 29.07 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44579044..44607465)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44929472..44958041)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 25 Neighboring gene STARR-positive B cell enhancer ABC_E8171 Neighboring gene STARR-positive B cell enhancer ABC_E547 Neighboring gene fuzzy planar cell polarity protein Neighboring gene adaptor-related protein complex 2, alpha 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E88 Neighboring gene carnitine palmitoyltransferase 1c Neighboring gene STARR-seq mESC enhancer starr_18822 Neighboring gene protein arginine N-methyltransferase 1

    Genomic regions, transcripts, and products

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC148222

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    testis-specific serine kinase substrate
    Names
    STK22 substrate 1
    clone 4
    serine/threonine kinase 22 substrate 1
    testis-specific kinase substrate
    testis-specific serine/threonine kinase substrate 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077591.1NP_001071059.1  testis-specific serine kinase substrate isoform 2

      See identical proteins and their annotated locations for NP_001071059.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple in-frame differences in the coding region, compared to variant 1, which results in a shorter protein (isoform 2).
      Source sequence(s)
      BC121827, BX630702, CJ047818
      Consensus CDS
      CCDS39946.1
      UniProtKB/TrEMBL
      Q147V4
      Related
      ENSMUSP00000079122.7, ENSMUST00000080233.9
      Conserved Domains (1) summary
      pfam15358
      Location:26525
      TSKS; Testis-specific serine kinase substrate
    2. NM_001417444.1NP_001404373.1  testis-specific serine kinase substrate isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC155806
    3. NM_001417445.1NP_001404374.1  testis-specific serine kinase substrate isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC155806, AC158231
    4. NM_001417446.1NP_001404375.1  testis-specific serine kinase substrate isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC155806, AC158231
    5. NM_011651.2NP_035781.2  testis-specific serine kinase substrate isoform 1

      See identical proteins and their annotated locations for NP_035781.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer protein (isoform 1).
      Source sequence(s)
      BC121827, BX630702, CJ047818, CN831975
      Consensus CDS
      CCDS52240.1
      UniProtKB/Swiss-Prot
      E9QJS9, O54887
      Related
      ENSMUSP00000112673.2, ENSMUST00000120929.9
      Conserved Domains (1) summary
      pfam15358
      Location:26585
      TSKS; Testis-specific serine kinase substrate

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44579044..44607465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540793.5XP_006540856.1  testis-specific serine kinase substrate isoform X3

      Conserved Domains (1) summary
      pfam15358
      Location:15580
      TSKS; Testis-specific serine kinase substrate
    2. XM_006540791.3XP_006540854.1  testis-specific serine kinase substrate isoform X1

      Conserved Domains (1) summary
      pfam15358
      Location:26610
      TSKS; Testis-specific serine kinase substrate
    3. XM_006540792.3XP_006540855.1  testis-specific serine kinase substrate isoform X2

      Conserved Domains (1) summary
      pfam15358
      Location:26601
      TSKS; Testis-specific serine kinase substrate
    4. XM_006540796.3XP_006540859.1  testis-specific serine kinase substrate isoform X6

      Conserved Domains (1) summary
      pfam15358
      Location:26573
      TSKS; Testis-specific serine kinase substrate
    5. XM_006540794.3XP_006540857.1  testis-specific serine kinase substrate isoform X4

      Conserved Domains (1) summary
      pfam15358
      Location:26576
      TSKS; Testis-specific serine kinase substrate
    6. XM_006540795.4XP_006540858.1  testis-specific serine kinase substrate isoform X5

      Conserved Domains (1) summary
      pfam15358
      Location:26492
      TSKS; Testis-specific serine kinase substrate