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    Gask1a golgi associated kinase 1A [ Mus musculus (house mouse) ]

    Gene ID: 245050, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gask1aprovided by MGI
    Official Full Name
    golgi associated kinase 1Aprovided by MGI
    Primary source
    MGI:MGI:3041196
    See related
    Ensembl:ENSMUSG00000038233 AllianceGenome:MGI:3041196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam198a; C730027P07Rik
    Summary
    Located in Golgi apparatus; endoplasmic reticulum; and extracellular region. Is expressed in naris; orbito-sphenoid; otic capsule; temporal bone petrous part; and turbinate bone primordium. Orthologous to human GASK1A (golgi associated kinase 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary adult (RPKM 2.9), limb E14.5 (RPKM 2.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gask1a in Genome Data Viewer
    Location:
    9 F4; 9 72.76 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121780057..121817379)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121950988..121988313)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25540 Neighboring gene cytochrome P450, family 8, subfamily b, polypeptide 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:121836139-121836440 Neighboring gene STARR-positive B cell enhancer mm9_chr9:121837482-121837783 Neighboring gene RIKEN cDNA 1700048O20 gene Neighboring gene STARR-seq mESC enhancer starr_25541 Neighboring gene protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:121902140-121902405 Neighboring gene predicted gene, 39463 Neighboring gene predicted gene, 39465 Neighboring gene predicted gene, 39464

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fam198a, a member of secreted kinase, secrets through caveolae biogenesis pathway. Wei Z, et al. Acta Biochim Biophys Sin (Shanghai), 2018 Oct 1. PMID 30188967
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Clone Names

    • MGC130602

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Golgi-associated kinase 1A
    Names
    family with sequence similarity 198, member A
    protein FAM198A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199927.2 → NP_001186856.1  Golgi-associated kinase 1A isoform 2 precursor

      See identical proteins and their annotated locations for NP_001186856.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences cause translation initiation at an upstream AUG and result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a longer N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC164092
      UniProtKB/Swiss-Prot
      Q3UY90
      Related
      ENSMUSP00000150724.3, ENSMUST00000214536.3
      Conserved Domains (1) summary
      pfam15051
      Location:236 → 493
      FAM198; FAM198 protein

    2. NM_001408673.1 → NP_001395602.1  Golgi-associated kinase 1A isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164092

    3. NM_001408674.1 → NP_001395603.1  Golgi-associated kinase 1A isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164092
      Related
      ENSMUSP00000151175.2, ENSMUST00000213773.2

    4. NM_001408675.1 → NP_001395604.1  Golgi-associated kinase 1A isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164092
      UniProtKB/Swiss-Prot
      Q3TYS0, Q3UTV8, Q3UY90, Q8C7H6
      Related
      ENSMUSP00000149755.3, ENSMUST00000215990.3

    5. NM_177743.6 → NP_808411.1  Golgi-associated kinase 1A isoform 1 precursor

      See identical proteins and their annotated locations for NP_808411.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC164092
      Consensus CDS
      CCDS52969.1
      UniProtKB/Swiss-Prot
      Q3UY90
      Related
      ENSMUSP00000040221.8, ENSMUST00000043011.9
      Conserved Domains (1) summary
      pfam15051
      Location:220 → 544
      FAM198; FAM198 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      121780057..121817379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512132.3 → XP_006512195.1  Golgi-associated kinase 1A isoform X1

      Conserved Domains (1) summary
      pfam15051
      Location:236 → 493
      FAM198; FAM198 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UY90.1 GenPept UniProtKB/Swiss-Prot:Q3UY90

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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