Scn10a sodium channel, voltage-gated, type X, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scn10aprovided by MGI
Official Full Name: sodium channel, voltage-gated, type X, alphaprovided by MGI
Primary source: MGI:MGI:108029
See related: Ensembl:ENSMUSG00000034533 AllianceGenome:MGI:108029
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PN3; SNS; Nav1.8
Summary: Enables voltage-gated sodium channel activity. Involved in behavioral response to pain; circadian rhythm; and detection of stimulus involved in sensory perception. Acts upstream of or within several processes, including cardiac conduction; regulation of atrial cardiac muscle cell membrane depolarization; and sodium ion transport. Located in C-fiber and plasma membrane. Is expressed in brain; ganglia; and heart. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 2. Orthologous to human SCN10A (sodium voltage-gated channel alpha subunit 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 1.0), CNS E18 (RPKM 0.5) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F3; 9 71.33 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (119437522..119548388, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (119608456..119719322, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nav1.8-expressing neurons control daily oscillations of food intake, body weight and gut microbiota in mice.
Title: Nav1.8-expressing neurons control daily oscillations of food intake, body weight and gut microbiota in mice.
Variant Intronic Enhancer Controls SCN10A-short Expression and Heart Conduction.
Title: Variant Intronic Enhancer Controls SCN10A-short Expression and Heart Conduction.
Modulations of Nav1.8 and Nav1.9 Channels in Monosodium Urate-Induced Gouty Arthritis in Mice.
Title: Modulations of Na(v)1.8 and Na(v)1.9 Channels in Monosodium Urate-Induced Gouty Arthritis in Mice.
Detrimental proarrhythmogenic interaction of Ca(2+)/calmodulin-dependent protein kinase II and NaV1.8 in heart failure.
Title: Detrimental proarrhythmogenic interaction of Ca(2+)/calmodulin-dependent protein kinase II and Na(V)1.8 in heart failure.
Contribution of the neuronal sodium channel NaV1.8 to sodium- and calcium-dependent cellular proarrhythmia.
Title: Contribution of the neuronal sodium channel Na(V)1.8 to sodium- and calcium-dependent cellular proarrhythmia.
Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis.
Title: Aberrant subchondral osteoblastic metabolism modifies Na(V)1.8 for osteoarthritis.
2 disease mutations (T790A and G1663S) in Nav1.8 that induce nociceptor hyperexcitability increase resurgent currents in DRG neurons which greatly prolong action potential duration and enhance repetitive firing. The transfected G1663S mutation doubled resurgent currents in rat DRGs, and the transfected T790A mutation increased them fourfold. Nav1.8 open-channel block is a major factor in Nav1.8-associated pain mechanisms.
Title: Increased Resurgent Sodium Currents in Nav1.8 Contribute to Nociceptive Sensory Neuron Hyperexcitability Associated with Peripheral Neuropathies.
required in all heat-resistant nociceptors to encode temperatures higher than approximately 46 degrees C
Title: Heat-resistant action potentials require TTX-resistant sodium channels Na(V)1.8 and Na(V)1.9.
We find that approximately 80% of neurons responsive to cold down to 1 degrees C do not express NaV1.8, and that the genetic deletion of NaV1.8 does not affect the relative number, distribution, or maximal response of cold-sensitive neurons. Furthermore, the deletion of NaV1.8 had no observable effect on transient cold-induced (>/=5 degrees C) behaviors in mice, as measured by the cold-plantar, cold-plate (5 and 10 deg...
Title: Cold sensing by Na(V)1.8-positive and Na(V)1.8-negative sensory neurons.
Nav1.8 role in the inflammatory pain.CXCL13, upregulated by peripheral inflammation, acts on CXCR5 on dorsal root ganglia neurons and activates p38, which increases Nav1.8 current density and further contributes to the maintenance of inflammatory pain.
Title: CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y09108 (e-PCR)
- UniSTS:163471

NoName (e-PCR)
- UniSTS:236281

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated sodium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated sodium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated sodium channel activity involved in cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in AV node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bundle of His cell action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac conduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of temperature stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane depolarization during action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane depolarization during action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of atrial cardiac muscle cell membrane depolarization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of atrial cardiac muscle cell membrane depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of atrial cardiac muscle cell membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in C-fiber	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
part_of clathrin complex	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated sodium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated sodium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated sodium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium channel protein type 10 subunit alpha

Names: peripheral nerve sodium channel 3; sensory neuron sodium channel; sodium channel protein type X subunit alpha; voltage gated sodium channel; voltage-gated sodium channel subunit alpha Nav1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205321.1 → NP_001192250.1 sodium channel protein type 10 subunit alpha isoform 1

See identical proteins and their annotated locations for NP_001192250.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC171201, AK157866

Consensus CDS

CCDS57716.1

UniProtKB/TrEMBL

A0A0R5RP34, K3W4P8

Related

ENSMUSP00000081845.6, ENSMUST00000084787.6

Conserved Domains (4) summary

cd13433
Location:1420 → 1472

Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

pfam00520
Location:1170 → 1428

Ion_trans; Ion transport protein

pfam06512
Location:903 → 1148

Na_trans_assoc; Sodium ion transport-associated

pfam16905
Location:1743 → 1800

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_009134.3 → NP_033160.2 sodium channel protein type 10 subunit alpha isoform 2

See identical proteins and their annotated locations for NP_033160.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC171201, AK157866

Consensus CDS

CCDS90682.1

UniProtKB/TrEMBL

A0A0R5RP33

Related

ENSMUSP00000148987.2, ENSMUST00000213392.2

Conserved Domains (4) summary

cd13433
Location:1419 → 1471

Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

pfam00520
Location:1169 → 1427

Ion_trans; Ion transport protein

pfam06512
Location:903 → 1147

Na_trans_assoc; Sodium ion transport-associated

pfam16905
Location:1742 → 1799

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

119437522..119548388 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313223.1 → XP_017168712.1 sodium channel protein type 10 subunit alpha isoform X4

UniProtKB/Swiss-Prot

Q62243, Q6EWG7, Q6KCH7, Q6QIY3, Q703F9

UniProtKB/TrEMBL

A0A0R5RP33

Conserved Domains (3) summary

cd13433
Location:1420 → 1472

Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

pfam00520
Location:1152 → 1428

Ion_trans; Ion transport protein

pfam06512
Location:903 → 1148

Na_trans_assoc; Sodium ion transport-associated
XM_017313221.1 → XP_017168710.1 sodium channel protein type 10 subunit alpha isoform X1

Conserved Domains (2) summary

pfam00520
Location:1151 → 1427

Ion_trans; Ion transport protein

pfam06512
Location:903 → 1147

Na_trans_assoc; Sodium ion transport-associated
XM_036154738.1 → XP_036010631.1 sodium channel protein type 10 subunit alpha isoform X3

Conserved Domains (2) summary

pfam00520
Location:663 → 893

Ion_trans; Ion transport protein

pfam06512
Location:903 → 1147

Na_trans_assoc; Sodium ion transport-associated
XM_017313222.3 → XP_017168711.1 sodium channel protein type 10 subunit alpha isoform X2

Conserved Domains (2) summary

pfam00520
Location:663 → 893

Ion_trans; Ion transport protein

pfam06512
Location:903 → 1148

Na_trans_assoc; Sodium ion transport-associated