Il2rg interleukin 2 receptor, gamma chain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il2rgprovided by MGI
Official Full Name: interleukin 2 receptor, gamma chainprovided by MGI
Primary source: MGI:MGI:96551
See related: Ensembl:ENSMUSG00000031304 AllianceGenome:MGI:96551
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: gc; p64; [g]c; CD132; gamma(c)
Summary: This gene encodes a transmembrane protein that is a common subunit of several interleukin receptor complexes. These receptors are comprised of alpha and beta subunits in addition to this gamma subunit. Signalling through this pathway in important in immune cell differentiation and function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Expression: Biased expression in thymus adult (RPKM 107.8), spleen adult (RPKM 68.6) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: X D; X 43.9 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (100307991..100311861, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (101264385..101268255, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PD-1 signaling negatively regulates the common cytokine receptor gamma chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity.
Title: PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity.
NFAT1 and NFkappaB regulates expression of the common gamma-chain cytokine receptor in activated T cells.
Title: NFAT1 and NFκB regulates expression of the common γ-chain cytokine receptor in activated T cells.
Protein abundance of the cytokine receptor gammac controls the thymic generation of innate-like T cells.
Title: Protein abundance of the cytokine receptor γc controls the thymic generation of innate-like T cells.
Improved engraftment of human peripheral blood mononuclear cells in NOG MHC double knockout mice generated using CRISPR/Cas9.
Title: Improved engraftment of human peripheral blood mononuclear cells in NOG MHC double knockout mice generated using CRISPR/Cas9.
Homodimeric sgammac has pathogenic roles to exacerbate rheumatoid arthritis progression with differentiation of local Th17, NKT1, and NKT17 cells. Therefore, sgammac is suggested as target of a therapeutic strategy for rheumatoid arthritis.
Title: Specific Inhibition of Soluble γc Receptor Attenuates Collagen-Induced Arthritis by Modulating the Inflammatory T Cell Responses.
Data indicate a role for ROR-gamma (RORgammat) and Bcl-XL protein (Bcl-xL) in limiting interleukin 2 receptor gamma chain (gammac) abundance at the cell surface.
Title: RORγt limits the amount of the cytokine receptor γc through the prosurvival factor Bcl-x(L) in developing thymocytes.
IL2RG mutations cause X-linked severe combined immunodeficiency in humans and mice that can be corrected by gene editing.
Title: Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Suggest that soluble common gamma chain may be one of the target molecules for the control of immunopathogenic progresses in COPD.
Title: Soluble common gamma chain exacerbates COPD progress through the regulation of inflammatory T cell response in mice.
Results indicate that conjugated-interleukin-2 (IL2) protein derived from NKTR-214 occupy interleukin-2 (IL2) receptor complex (IL2Ralphabetagamma) to a greater extent compared to free-IL2 protein.
Title: Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy.
Renal lesions are indeed modulated by intrinsic glomerular cells through the gamma-C/IL-2-beta receptor response, to date classically described only in immune cells.
Title: Glomerular common gamma chain confers B- and T-cell-independent protection against glomerulonephritis.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (19) 1 citation
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13565 (e-PCR)
- UniSTS:181319

U21795 (e-PCR)
- UniSTS:160897

Il2rg (e-PCR), detects polymorphism
- UniSTS:256438

Il2rg (e-PCR), detects polymorphism
- UniSTS:143560

Il2rg (e-PCR), detects polymorphism
- UniSTS:256979

PMC155645P2 (e-PCR)
- UniSTS:271344

U21795 (e-PCR)
- UniSTS:125695

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables coreceptor activity	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-15 receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-15 receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables interleukin-2 binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-15-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-15-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in interleukin-2-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-2-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-7-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-7-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-9-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-9-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of lymphocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mature B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of immunoglobulin production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytokine receptor common subunit gamma

Names: IL-2 receptor subunit gamma; IL-2R subunit gamma; common gamma chain; gamma C receptor; interleukin-2 receptor subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308535.1 → NP_001295464.1 cytokine receptor common subunit gamma isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (b) uses an alternate splice site, which results in a frameshift, compared to variant a. The encoded isoform (b) is shorter than isoform a and has a distinct C-terminus.

Source sequence(s)

AK143669, AL683892, KC815469

UniProtKB/TrEMBL

V5SIM2

Conserved Domains (2) summary

cd00063
Location:154 → 218

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:59 → 151

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_013563.4 → NP_038591.1 cytokine receptor common subunit gamma isoform a precursor

See identical proteins and their annotated locations for NP_038591.1

Status: REVIEWED

Description

Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK143669, AL683892

Consensus CDS

CCDS30312.1

UniProtKB/Swiss-Prot

P34902

UniProtKB/TrEMBL

Q3UPA9

Related

ENSMUSP00000033664.8, ENSMUST00000033664.14

Conserved Domains (2) summary

cd00063
Location:154 → 247

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:59 → 151

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

100307991..100311861 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318396.3 → XP_017173885.1 cytokine receptor common subunit gamma isoform X1

Conserved Domains (2) summary

cd00063
Location:181 → 274

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:86 → 158

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...