Slc26a9 solute carrier family 26, member 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc26a9provided by MGI
Official Full Name: solute carrier family 26, member 9provided by MGI
Primary source: MGI:MGI:2444594
See related: Ensembl:ENSMUSG00000042268 AllianceGenome:MGI:2444594
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E030002L01Rik
Summary: Enables chloride channel activity; chloride:bicarbonate antiporter activity; and identical protein binding activity. Involved in monoatomic anion transport. Acts upstream of or within bicarbonate transport; chloride transport; and regulation of pH. Located in apical plasma membrane. Is expressed in several structures, including adrenal gland; nervous system; respiratory system; and sensory organ. Orthologous to human SLC26A9 (solute carrier family 26 member 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in stomach adult (RPKM 21.9) and lung adult (RPKM 13.8) See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 57.18 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (131671760..131699242)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (131744022..131771504)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans.
Title: SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans.
Hydrokinetic pancreatic function and insulin secretion are moduled by Cl(-) uniporter Slc26a9 in mice.
Title: Hydrokinetic pancreatic function and insulin secretion are moduled by Cl(-) uniporter Slc26a9 in mice.
conformational transitions of Slc26a9, supporting a rapid alternate-access mechanism which mediates uncoupled chloride transport with negligible bicarbonate or sulfate permeability, is reported.
Title: Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport.
The chloride channel/transporter Slc26a9 regulates the systemic arterial pressure and renal chloride excretion.
Title: The chloride channel/transporter Slc26a9 regulates the systemic arterial pressure and renal chloride excretion.
SLC26A9 is activated in airway inflammation. Slc26a9-deficient mice exhibited IL-13-induced airway mucus obstruction. SLC26A9-mediated Cl- secretion is essential for preventing airway obstruction in allergic airway disease.
Title: SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation.
Cellular HCO(3)(-) secretion, likely through SLC26A9, is the dominant mechanism whereby gastric mucosal surface pH transiently increases in response to photodamage.
Title: Damage to the gastric epithelium activates cellular bicarbonate secretion via SLC26A9 Cl(-)/HCO(3)(-).
Slc26a9 has three discrete physiological modes: nCl(-)-HCO(3)(-) exchanger, Cl(-) channel, and Na(+)-anion cotransporter.
Title: Slc26a9--anion exchanger, channel and Na+ transporter.
Slc26a9 plays an essential role in gastric acid secretion via effects on the viability of tubulovesicles/secretory canaliculi and by regulating chloride secretion in parietal cells.
Title: Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach.
Slc26a9 functions as an electrogenic nCl-/HCO3- exchanger, suggesting a role in pulmonary and gastric HCO3- secretion and/or CO2 transport.
Title: Physiology of electrogenic SLC26 paralogues.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)
Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:547065

Slc26a9 (e-PCR), detects polymorphism
- UniSTS:547065

Slc26a9 (e-PCR), detects polymorphism
- UniSTS:547066

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables bicarbonate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bicarbonate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables chloride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride:bicarbonate antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables oxalate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables solute:inorganic anion antiporter activity	ISO Inferred from Sequence Orthology more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bicarbonate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chloride transport	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic anion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic anion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of pH	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 26 member 9

Names: SLC26A9 anion transporter/exchanger; anion transporter/exchanger protein 9; anion transporter/exchanger-9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177243.4 → NP_796217.2 solute carrier family 26 member 9

See identical proteins and their annotated locations for NP_796217.2

Status: VALIDATED

Source sequence(s)

AK078966, AK086815

Consensus CDS

CCDS15273.1

UniProtKB/Swiss-Prot

Q8BU91, Q8BVC3

UniProtKB/TrEMBL

A0A0R4J0F7

Related

ENSMUSP00000036916.4, ENSMUST00000049027.10

Conserved Domains (1) summary

TIGR00815
Location:57 → 733

sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

131671760..131699242

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529700.2 → XP_006529763.1 solute carrier family 26 member 9 isoform X1

See identical proteins and their annotated locations for XP_006529763.1

UniProtKB/Swiss-Prot

Q8BU91, Q8BVC3

UniProtKB/TrEMBL

A0A0R4J0F7

Conserved Domains (1) summary

TIGR00815
Location:57 → 733

sulP; high affinity sulphate transporter 1
XM_030254980.1 → XP_030110840.1 solute carrier family 26 member 9 isoform X2

Conserved Domains (1) summary

TIGR00815
Location:7 → 457

sulP; high affinity sulphate transporter 1
XM_006529701.1 → XP_006529764.1 solute carrier family 26 member 9 isoform X2

Conserved Domains (1) summary

TIGR00815
Location:7 → 457

sulP; high affinity sulphate transporter 1