Mir181a-1 microRNA 181a-1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mir181a-1provided by MGI
Official Full Name: microRNA 181a-1provided by MGI
Primary source: MGI:MGI:3629589
See related: Ensembl:ENSMUSG00000065565 miRBase:MI0000697; AllianceGenome:MGI:3629589
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mirn213; miR-213; Mirn181a-1; mir-181a-1; mmu-mir-213
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1 E4; 1 60.68 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (137894193..137894279)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (137966455..137966541)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-181a-5p may regulate cell proliferation and autophagy in myopia and the associated retinopathy.
Title: MiR-181a-5p may regulate cell proliferation and autophagy in myopia and the associated retinopathy.
Intermittent hypoxia increased the expression of ESM1 and ICAM-1 in vascular endothelial cells via the downregulation of microRNA-181a1.
Title: Intermittent hypoxia increased the expression of ESM1 and ICAM-1 in vascular endothelial cells via the downregulation of microRNA-181a1.
MicroRNA-181a-5p alleviates acute liver failure in mice by inhibiting HMGB1.
Title: MicroRNA-181a-5p alleviates acute liver failure in mice by inhibiting HMGB1.
miR-181a-5p targets DDX3X to inhibit the progression of osteoarthritis via NF-KappaB signaling pathway.
Title: miR-181a-5p targets DDX3X to inhibit the progression of osteoarthritis via NF-ΚB signaling pathway.
MicroRNA-181a-5p Curbs Osteogenic Differentiation and Bone Formation Partially Through Impairing Runx1-Dependent Inhibition of AIF-1 Transcription.
Title: MicroRNA-181a-5p Curbs Osteogenic Differentiation and Bone Formation Partially Through Impairing Runx1-Dependent Inhibition of AIF-1 Transcription.
MiR-181a-5p promotes osteogenesis by targeting BMP3.
Title: MiR-181a-5p promotes osteogenesis by targeting BMP3.
miR-181a Improved Renal Inflammation by Targeting TNF-alpha in a Diabetic Nephropathy Animal Model.
Title: miR-181a Improved Renal Inflammation by Targeting TNF-α in a Diabetic Nephropathy Animal Model.
Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell-Specific Changes in the Kidney and Increases Blood Pressure.
Title: Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell-Specific Changes in the Kidney and Increases Blood Pressure.
miR-181a regulates the host immune response against Schistosoma japonicum infection through the TLR4 receptor pathway.
Title: miR-181a regulates the host immune response against Schistosoma japonicum infection through the TLR4 receptor pathway.
Inhibition of miR-181a attenuates sepsis-induced inflammation and apoptosis by activating Nrf2 and inhibiting NF-kappaB pathways via targeting SIRT1.
Title: Inhibition of miR-181a attenuates sepsis-induced inflammation and apoptosis by activating Nrf2 and inhibiting NF-κB pathways via targeting SIRT1.

Submit: New GeneRIF Correction See all GeneRIFs (27)

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within long-term synaptic potentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IEP Inferred from Expression Pattern more info	PubMed

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.