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    Rgs21 regulator of G-protein signalling 21 [ Mus musculus (house mouse) ]

    Gene ID: 624910, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rgs21provided by MGI
    Official Full Name
    regulator of G-protein signalling 21provided by MGI
    Primary source
    MGI:MGI:3645243
    See related
    Ensembl:ENSMUSG00000098509 AllianceGenome:MGI:3645243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG624910
    Summary
    Involved in sensory perception of taste and transmission of nerve impulse. Orthologous to human RGS21 (regulator of G protein signaling 21). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human all
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    Genomic context

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    See Rgs21 in Genome Data Viewer
    Location:
    1 F; 1 62.66 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (144392388..144443185, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (144519690..144567667, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02538 Neighboring gene regulator of G-protein signaling 1 Neighboring gene STARR-positive B cell enhancer ABC_E5816 Neighboring gene predicted gene 7266 Neighboring gene STARR-seq mESC enhancer starr_02539 Neighboring gene STARR-seq mESC enhancer starr_02540 Neighboring gene regulator of G-protein signaling 18 Neighboring gene STARR-seq mESC enhancer starr_02541 Neighboring gene cytokine receptor-like factor 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The stability of tastant detection by mouse lingual chemosensory tissue requires Regulator of G protein Signaling-21 (RGS21). Schroer AB, et al. Chem Senses, 2021 Jan 1. PMID 34718440, Free PMC Article
    2. Development of Full Sweet, Umami, and Bitter Taste Responsiveness Requires Regulator of G protein Signaling-21 (RGS21). Schroer AB, et al. Chem Senses, 2018 May 23. PMID 29701767, Free PMC Article
    3. RGS21, a regulator of taste and mucociliary clearance? Kimple AJ, et al. Laryngoscope, 2014 Mar. PMID 23908053, Free PMC Article
    4. Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. Cohen SP, et al. J Biol Chem, 2012 Dec 7. PMID 23095746, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The stability of tastant detection by mouse lingual chemosensory tissue requires Regulator of G protein Signaling-21 (RGS21).
      Title: The stability of tastant detection by mouse lingual chemosensory tissue requires Regulator of G protein Signaling-21 (RGS21).
    2. RGS21 protein a regulator of taste and mucociliary clearance.
      Title: RGS21, a regulator of taste and mucociliary clearance?
    3. RGS21 modulates bitter taste signal transduction.
      Title: Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in sensory perception of bitter taste IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sweet taste IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of umami taste IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmission of nerve impulse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulator of G-protein signaling 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290269.2 → NP_001277198.1  regulator of G-protein signaling 21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158950
      Consensus CDS
      CCDS69952.1
      UniProtKB/TrEMBL
      V9GXQ3
      Related
      ENSMUSP00000139265.2, ENSMUST00000184189.3
      Conserved Domains (1) summary
      cl02565
      Location:25 → 135
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. NM_001421024.1 → NP_001407953.1  regulator of G-protein signaling 21 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158950
      UniProtKB/TrEMBL
      A0A5S9EHU3

    3. NM_001421025.1 → NP_001407954.1  regulator of G-protein signaling 21 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158950
      UniProtKB/TrEMBL
      A0A5S9EHU9

    RNA

    1. NR_110891.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158950

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      144392388..144443185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152654.1 → XP_036008547.1  regulator of G-protein signaling 21 isoform X3

      UniProtKB/TrEMBL
      A0A5S9EHU9
      Conserved Domains (1) summary
      cl02565
      Location:4 → 114
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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