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    Trmt11 tRNA methyltransferase 11 [ Mus musculus (house mouse) ]

    Gene ID: 73681, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Trmt11provided by MGI
    Official Full Name
    tRNA methyltransferase 11provided by MGI
    Primary source
    MGI:MGI:1920931
    See related
    Ensembl:ENSMUSG00000019792 AllianceGenome:MGI:1920931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410075D05Rik; 3110045I18Rik
    Summary
    Predicted to enable methyltransferase activity. Predicted to be involved in methylation and tRNA processing. Predicted to be active in cytoplasm. Is expressed in submandibular gland primordium. Orthologous to human TRMT11 (tRNA methyltransferase 11 homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 1.8), CNS E11.5 (RPKM 1.6) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trmt11 in Genome Data Viewer
    Location:
    10 A4; 10 17.07 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (30410218..30477598, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (30534225..30602149, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40622 Neighboring gene predicted gene, 22623 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:30320514-30320623 Neighboring gene STARR-positive B cell enhancer ABC_E6828 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:30338273-30338456 Neighboring gene STARR-seq mESC enhancer starr_26197 Neighboring gene predicted gene, 20300 Neighboring gene histidine triad nucleotide binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_26199 Neighboring gene nuclear receptor coactivator 7 Neighboring gene STARR-seq mESC enhancer starr_26200 Neighboring gene STARR-positive B cell enhancer ABC_E5123 Neighboring gene STARR-seq mESC enhancer starr_26202 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA (guanine(10)-N2)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (guanine(10)-N2)-methyltransferase homolog
    Names
    tRNA guanosine-2'-O-methyltransferase TRM11 homolog
    tRNA methyltransferase 11 homolog
    NP_001345735.1
    NP_082880.2
    XP_006512940.1
    XP_006512943.1
    XP_030101177.1
    XP_030101179.1
    XP_030101180.1
    XP_036011940.1
    XP_036011941.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358806.1 → NP_001345735.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153899, AK010722, AK032943, BG083636, BY259542
      Conserved Domains (1) summary
      COG1041
      Location:2 → 173
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    2. NM_028604.3 → NP_082880.2  tRNA (guanine(10)-N2)-methyltransferase homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153899, AK010722, AK032943, BG083636, BY259542
      Consensus CDS
      CCDS23763.1
      UniProtKB/Swiss-Prot
      Q80Y71, Q9CWH5
      UniProtKB/TrEMBL
      E9QKG3
      Related
      ENSMUSP00000019927.7, ENSMUST00000019927.7
      Conserved Domains (2) summary
      COG1041
      Location:9 → 398
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
      cl17173
      Location:190 → 321
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      30410218..30477598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512877.4 → XP_006512940.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X1

      UniProtKB/Swiss-Prot
      Q80Y71, Q9CWH5
      Conserved Domains (1) summary
      COG1041
      Location:9 → 346
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    2. XM_030245319.2 → XP_030101179.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X5

      Conserved Domains (1) summary
      COG1041
      Location:2 → 173
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    3. XM_006512880.5 → XP_006512943.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X4

      Conserved Domains (1) summary
      COG1041
      Location:1 → 200
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    4. XM_030245317.2 → XP_030101177.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X3

      UniProtKB/Swiss-Prot
      Q80Y71, Q9CWH5
      Conserved Domains (1) summary
      COG1041
      Location:5 → 330
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    5. XM_030245320.2 → XP_030101180.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X5

      Conserved Domains (1) summary
      COG1041
      Location:2 → 173
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    6. XM_036156047.1 → XP_036011940.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X2

      UniProtKB/Swiss-Prot
      Q80Y71, Q9CWH5
      Conserved Domains (1) summary
      COG1041
      Location:7 → 335
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

    7. XM_036156048.1 → XP_036011941.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform X5

      Conserved Domains (1) summary
      COG1041
      Location:2 → 173
      Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWH5.1 GenPept UniProtKB/Swiss-Prot:Q9CWH5

    Gene LinkOut

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