Hmg20b high mobility group 20B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hmg20bprovided by MGI
Official Full Name: high mobility group 20Bprovided by MGI
Primary source: MGI:MGI:1341190
See related: Ensembl:ENSMUSG00000020232 AllianceGenome:MGI:1341190
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hmgx2; BRAF35; Hmgxb2; Smarce1r
Summary: Predicted to enable four-way junction DNA binding activity. Acts upstream of or within negative regulation of protein sumoylation; positive regulation of neuron differentiation; and skeletal muscle cell differentiation. Predicted to be located in condensed nuclear chromosome and nuclear body. Predicted to be part of BRCA2-BRAF35 complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; foregut; and genitourinary system. Orthologous to human HMG20B (high mobility group 20B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in duodenum adult (RPKM 74.1), adrenal adult (RPKM 70.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (81181880..81186777, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81346046..81350943, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our data uncover a mechanism of regulation of the LSD1-CoREST complex and provide a molecular explanation for the antagonism between Braf35 and iBraf in neuronal differentiation.
Title: Control of neuronal differentiation by sumoylation of BRAF35, a subunit of the LSD1-CoREST histone demethylase complex.
Hmg20b acts as an inhibitor of erythroid differentiation, through the down-regulation of genes involved in differentiation
Title: The DNA binding factor Hmg20b is a repressor of erythroid differentiation.
beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35
Title: The interaction with HMG20a/b proteins suggests a potential role for beta-dystrobrevin in neuronal differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW610687 (e-PCR)
- UniSTS:180083

RH130154 (e-PCR)
- UniSTS:213441

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables four-way junction DNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	NAS Non-traceable Author Statement more info	PubMed
involved_in chromatin remodeling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of BRCA2-BRAF35 complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

Names: BRCA2-associated factor 35; HMG box-containing protein 20B; SMARCE1-related protein; high mobility group 20 B; high mobility group protein 20 B; structural DNA-binding protein BRAF35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163165.2 → NP_001156637.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform c

See identical proteins and their annotated locations for NP_001156637.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (c).

Source sequence(s)

AC155937

Consensus CDS

CCDS24055.1

UniProtKB/Swiss-Prot

Q9NSF7, Q9NSF8, Q9Z104

UniProtKB/TrEMBL

Q3U1L0, Q3U1X5

Related

ENSMUSP00000100961.3, ENSMUST00000105324.9

Conserved Domains (1) summary

cd01390
Location:70 → 134

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
NM_001163166.1 → NP_001156638.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform c

See identical proteins and their annotated locations for NP_001156638.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (c).

Source sequence(s)

AK153816, BE956207

Consensus CDS

CCDS24055.1

UniProtKB/Swiss-Prot

Q9NSF7, Q9NSF8, Q9Z104

UniProtKB/TrEMBL

Q3U1L0, Q3U1X5

Related

ENSMUSP00000100960.2, ENSMUST00000105323.8

Conserved Domains (1) summary

cd01390
Location:70 → 134

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
NM_001428541.1 → NP_001415470.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (4), as well as variants 5 and 6, encodes the longest isoform (a).

Source sequence(s)

AC155937
NM_001428542.1 → NP_001415471.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform a

Status: VALIDATED

Source sequence(s)

AC155937
NM_001428543.1 → NP_001415472.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform a

Status: VALIDATED

Source sequence(s)

AC155937
NM_001428544.1 → NP_001415473.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform b

Status: VALIDATED

Source sequence(s)

AC155937

UniProtKB/TrEMBL

Q3U1X5
NM_001428545.1 → NP_001415474.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform d

Status: VALIDATED

Source sequence(s)

AC155937

UniProtKB/TrEMBL

Q3U1X5
NM_001428546.1 → NP_001415475.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (9), as well as variant 10, encodes isoform e.

Source sequence(s)

AC155937

UniProtKB/TrEMBL

Q05DT2
NM_001428547.1 → NP_001415476.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform e

Status: VALIDATED

Source sequence(s)

AC155937

UniProtKB/TrEMBL

Q05DT2
NM_010440.4 → NP_034570.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform c

See identical proteins and their annotated locations for NP_034570.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform c. Variants 1-3 all encode the same isoform (c).

Source sequence(s)

AC155937

Consensus CDS

CCDS24055.1

UniProtKB/Swiss-Prot

Q9NSF7, Q9NSF8, Q9Z104

UniProtKB/TrEMBL

Q3U1L0, Q3U1X5

Related

ENSMUSP00000020454.5, ENSMUST00000020454.11

Conserved Domains (1) summary

cd01390
Location:70 → 134

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

81181880..81186777 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155645.1 → XP_036011538.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform X2

Conserved Domains (2) summary

PRK10246
Location:57 → 167

PRK10246; exonuclease subunit SbcC; Provisional

smart00935
Location:26 → 90

OmpH; Outer membrane protein (OmpH-like)
XM_006513248.3 → XP_006513311.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform X1

Conserved Domains (3) summary

smart00935
Location:190 → 254

OmpH; Outer membrane protein (OmpH-like)

cd01390
Location:70 → 134

HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...

pfam15258
Location:314 → 400

FAM222A; Protein family of FAM222A
XM_036155646.1 → XP_036011539.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform X2

Conserved Domains (2) summary

PRK10246
Location:57 → 167

PRK10246; exonuclease subunit SbcC; Provisional

smart00935
Location:26 → 90

OmpH; Outer membrane protein (OmpH-like)
XM_006513249.5 → XP_006513312.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform X1

Conserved Domains (3) summary

smart00935
Location:190 → 254

OmpH; Outer membrane protein (OmpH-like)

cd01390
Location:70 → 134

HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...

pfam15258
Location:314 → 400

FAM222A; Protein family of FAM222A