Krt10 keratin 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt10provided by MGI
Official Full Name: keratin 10provided by MGI
Primary source: MGI:MGI:96685
See related: Ensembl:ENSMUSG00000019761 AllianceGenome:MGI:96685
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K10; K1C1; Krt1-10; Krt-1.10; D130054E02Rik
Summary: Enables cytoskeletal protein binding activity. Involved in positive regulation of epidermis development. Acts upstream of or within several processes, including cellular response to calcium ion; intermediate filament organization; and keratinocyte development. Located in cytoplasm and keratin filament. Is active in cornified envelope. Is expressed in several structures, including alimentary system; lower urinary tract; penis; sensory organ; and skin. Used to study epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in epidermolytic hyperkeratosis and epidermolytic hyperkeratosis 2. Orthologous to human KRT10 (keratin 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in stomach adult (RPKM 238.7) and limb E14.5 (RPKM 51.3) See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 62.92 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (99276080..99288631, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (99385254..99397449, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription Factors Runx1 and Runx3 Suppress Keratin Expression in Undifferentiated Keratinocytes.
Title: Transcription Factors Runx1 and Runx3 Suppress Keratin Expression in Undifferentiated Keratinocytes.
These findings indicate that alpha112:alpha556 (IV) network, which is the only network that includes the alpha6(IV) chain, is one regulator of KRT10 expression in keratinization of oral mucosal epithelium.
Title: Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium.
This study demonstrates that the loss of the main cytoskeletal components of plantar epidermis, i.e. K2 and K10, can be only partly compensated by the upregulation of other keratins.
Title: Keratins K2 and K10 are essential for the epidermal integrity of plantar skin.
The Krt1(-/-);Krt10(-/-) mice showed premature loss of nuclei during epidermal differentiation and lower levels of emerin, lamin A/C and Sun1, revealing a previously unknown function for IFs in maintaining nuclear integrity in the upper epidermis.
Title: Deletion of K1/K10 does not impair epidermal stratification but affects desmosomal structure and nuclear integrity.
Aging enhances susceptibility to pneumococcal pneumonia in a K10-dependent manner.
Title: Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia.
The absence of keratin 10 stimulates cell differentiation and proliferation in sebacous glands.
Title: Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation.
role in inducing severe abnormalities in oral mucosa
Title: Severe abnormalities in the oral mucosa induced by suprabasal expression of epidermal keratin K10 in transgenic mice.
expression in epidermal basal layer inhibits cell proliferation and prevents skin tumorigenesis
Title: The expression of keratin k10 in the basal layer of the epidermis inhibits cell proliferation and prevents skin tumorigenesis.
loss of a keratin, a cytoskeletal protein, reduces tumor formation
Title: Loss of keratin 10 leads to mitogen-activated protein kinase (MAPK) activation, increased keratinocyte turnover, and decreased tumor formation in mice.
The epidermis of adult K10-/- mice displayed hyperproliferation of basal keratinocytes and increased cell size,accompanied by the induction of c-Myc, cyclin D1, 14-3-3sigma and wound healing keratins K6 and K16.
Title: Hyperproliferation, induction of c-Myc and 14-3-3sigma, but no cell fragility in keratin-10-null mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Krt1-10 (e-PCR), detects polymorphism
- UniSTS:143735

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IGI Inferred from Genetic Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of skin epidermis	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermis development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epidermis development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intermediate filament organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within keratinocyte development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within keratinocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptide cross-linking	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein heterotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein heterotetramerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within stem cell differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
located_in cornified envelope	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IDA Inferred from Direct Assay more info	PubMed
located_in keratin filament	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: keratin, type I cytoskeletal 10

Names: 56 kDa cytokeratin; CK-10; cytokeratin-10; epidermal keratin 10; intermediate filament protein; keratin complex 1, acidic, gene 10; keratin, type I cytoskeletal 59 kDa; suprabasal cytokeratin 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010660.2 → NP_034790.2 keratin, type I cytoskeletal 10

See identical proteins and their annotated locations for NP_034790.2

Status: VALIDATED

Source sequence(s)

AI173281, AK076508, BB648004

Consensus CDS

CCDS25380.1

UniProtKB/TrEMBL

A2A513

Related

ENSMUSP00000099420.5, ENSMUST00000103131.5

Conserved Domains (1) summary

pfam00038
Location:134 → 443

Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

99276080..99288631 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248768.3 → XP_011247070.1 keratin, type I cytoskeletal 10 isoform X1

Conserved Domains (1) summary

pfam00038
Location:134 → 443

Filament; Intermediate filament protein