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    Or5au1 olfactory receptor family 5 subfamily AU member 1 [ Mus musculus (house mouse) ]

    Gene ID: 258420, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Or5au1provided by MGI
    Official Full Name
    olfactory receptor family 5 subfamily AU member 1provided by MGI
    Primary source
    MGI:MGI:3030055
    See related
    Ensembl:ENSMUSG00000044286 AllianceGenome:MGI:3030055
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Olfr221; MOR205-1; MOR205-2; Olfr1514; Olfr221-ps1
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Orthologs
    human all
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    Genomic context

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    See Or5au1 in Genome Data Viewer
    Location:
    14 C2; 14 26.77 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (52272631..52273566, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (52035174..52036109, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 40 Neighboring gene predicted gene, 16617 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:52628339-52628522 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:52628697-52628806 Neighboring gene zinc finger protein 219 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:52639962-52640145 Neighboring gene transmembrane protein 253 Neighboring gene STARR-seq mESC enhancer starr_36687 Neighboring gene STARR-seq mESC enhancer starr_36689 Neighboring gene STARR-seq mESC enhancer starr_36690 Neighboring gene STARR-seq mESC enhancer starr_36694 Neighboring gene predicted gene, 22354 Neighboring gene 60S ribosomal protein L17 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures. de March CA, et al. Mol Cell Neurosci, 2020 Apr. PMID 32061665, Free PMC Article
    2. Odorant and vomeronasal receptor genes in two mouse genome assemblies. Zhang X, et al. Genomics, 2004 May. PMID 15081110
    3. The olfactory receptor gene superfamily of the mouse. Zhang X, et al. Nat Neurosci, 2002 Feb. PMID 11802173
    4. Different evolutionary processes shaped the mouse and human olfactory receptor gene families. Young JM, et al. Hum Mol Genet, 2002 Mar 1. PMID 11875048
    5. Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels. Young JM, et al. Genome Biol, 2003. PMID 14611657, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This odorant receptor, Olfr221, responds to the odorant whiskey lactone in both in vivo and in vitro assays.
      Title: Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC182601, MGC184004, MGC184008

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables odorant binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of smell ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    olfactory receptor 221
    Names
    GA_x6K02SYYB8M-929-258
    GA_x6K02T2RJGY-959918-960853
    olfactory receptor 1514
    olfactory receptor 221, pseudogene 1
    olfactory receptor MOR205-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001808.2 → NP_001001808.2  olfactory receptor 221

      See identical proteins and their annotated locations for NP_001001808.2

      Status: VALIDATED

      Source sequence(s)
      AC157572
      Consensus CDS
      CCDS27050.1
      UniProtKB/TrEMBL
      B2RVX8, Q7TQP7
      Related
      ENSMUSP00000150231.2, ENSMUST00000214342.2
      Conserved Domains (2) summary
      pfam00001
      Location:41 → 290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:31 → 304
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      52272631..52273566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_146428.1: Suppressed sequence

      Description
      NM_146428.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version

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