U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Wbp2nl WBP2 N-terminal like [ Mus musculus (house mouse) ]

    Gene ID: 74716, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wbp2nlprovided by MGI
    Official Full Name
    WBP2 N-terminal likeprovided by MGI
    Primary source
    MGI:MGI:1921966
    See related
    Ensembl:ENSMUSG00000022455 AllianceGenome:MGI:1921966
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAWP; 4930521I23Rik
    Summary
    Predicted to enable WW domain binding activity; chromatin DNA binding activity; and transcription coactivator activity. Predicted to be involved in egg activation; male pronucleus assembly; and positive regulation of DNA-templated transcription. Predicted to act upstream of or within female pronucleus assembly. Predicted to be located in perinuclear theca; sperm flagellum; and sperm head. Predicted to be active in nucleus. Orthologous to human WBP2NL (WBP2 N-terminal like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 60.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Wbp2nl in Genome Data Viewer
    Location:
    15 E1; 15 38.56 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82183126..82198848)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82298925..82314647)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 45 Neighboring gene predicted gene, 52180 Neighboring gene septin 3 Neighboring gene STARR-seq mESC enhancer starr_39292 Neighboring gene N-acetyl galactosaminidase, alpha Neighboring gene PH domain containing endocytic trafficking adaptor 2 Neighboring gene nuclear encoded rRNA 5S 41

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables WW domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in egg activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within female pronucleus assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in male pronucleus assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear theca ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in sperm flagellum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm head IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm head ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    postacrosomal sheath WW domain-binding protein
    Names
    WW domain-binding protein 2-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029066.1NP_083342.1  postacrosomal sheath WW domain-binding protein

      See identical proteins and their annotated locations for NP_083342.1

      Status: PROVISIONAL

      Source sequence(s)
      BC119520
      Consensus CDS
      CCDS37158.1
      UniProtKB/Swiss-Prot
      Q9D529
      Related
      ENSMUSP00000023089.4, ENSMUST00000023089.5
      Conserved Domains (3) summary
      cd13214
      Location:31129
      PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam10349
      Location:103225
      WWbp; WW-domain ligand protein
      cl23807
      Location:254327
      WWbp; WW-domain ligand protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      82183126..82198848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316772.2XP_017172261.1  postacrosomal sheath WW domain-binding protein isoform X1

      Conserved Domains (2) summary
      PTZ00436
      Location:182345
      PTZ00436; 60S ribosomal protein L19-like protein; Provisional
      cd13214
      Location:48146
      PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain