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    Itgae integrin subunit alpha E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83577, updated on 9-Dec-2024

    Summary

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    Symbol
    Itgaeprovided by RGD
    Full Name
    integrin subunit alpha Eprovided by RGD
    Primary source
    RGD:621644
    See related
    EnsemblRapid:ENSRNOG00000046639 AllianceGenome:RGD:621644
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Located in cell surface. Orthologous to human ITGAE (integrin subunit alpha E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 75.0), Spleen (RPKM 61.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Itgae in Genome Data Viewer
    Location:
    10q24
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (58203331..58262606)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57704813..57764093)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59652324..59711885)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase kinase 1 Neighboring gene nuclear cap binding subunit 3 Neighboring gene histone H3 associated protein kinase Neighboring gene coiled-coil-helix-coiled-coil-helix domain-containing protein 2-like Neighboring gene uncharacterized LOC108352105

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dominant tolerance to kidney allografts induced by anti-donor MHC class II antibodies: cooperation between T and non-T CD103+ cells. Degauque N, et al. J Immunol, 2006 Apr 1. PMID 16547225
    2. Sequence analysis of rat integrin alpha E1 and alpha E2 subunits: tissue expression reveals phenotypic similarities between intraepithelial lymphocytes and dendritic cells in lymph. Brenan M, et al. Eur J Immunol, 1997 Nov. PMID 9394838
    3. Integrin αEβ7 is involved in the intestinal barrier injury of sepsis. Sun JK, et al. Aging (Albany NY), 2022 Jan 18. PMID 35042191, Free PMC Article
    4. Phenotype and function of GM-CSF independent dendritic cells generated by long-term propagation of rat bone marrow cells. Yan H, et al. Cell Immunol, 2004 Jun. PMID 15474526
    5. The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Chae WJ, et al. Proc Natl Acad Sci U S A, 2006 Jun 20. PMID 16769892, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Integrin alphaEbeta7 is involved in the intestinal barrier injury of sepsis.
      Title: Integrin αEβ7 is involved in the intestinal barrier injury of sepsis.
    2. transfer of tolerance requires the presence of both T cells and CD103(+) dendritic cells
      Title: Dominant tolerance to kidney allografts induced by anti-donor MHC class II antibodies: cooperation between T and non-T CD103+ cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    integrin alpha-E
    Names
    integrin alpha E1, epithelial-associated
    integrin, alpha E, epithelial-associated

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031768.3 → NP_113956.2  integrin alpha-E precursor

      See identical proteins and their annotated locations for NP_113956.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HGH9, M0R6T8, O88341
      Related
      ENSRNOP00000065145.1, ENSRNOT00000073209.5
      Conserved Domains (3) summary
      smart00191
      Location:568 → 626
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:196 → 373
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam08441
      Location:669 → 952
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      58203331..58262606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086945.1 → XP_038942873.1  integrin alpha-E isoform X1

      UniProtKB/TrEMBL
      O88341
      Related
      ENSRNOP00000112317.1, ENSRNOT00000168737.1
      Conserved Domains (4) summary
      smart00191
      Location:568 → 626
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:196 → 373
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1108 → 1122
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:669 → 952
      Integrin_alpha2; Integrin alpha
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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