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    Ms4a12 membrane-spanning 4-domains, subfamily A, member 12 [ Mus musculus (house mouse) ]

    Gene ID: 381213, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ms4a12provided by MGI
    Official Full Name
    membrane-spanning 4-domains, subfamily A, member 12provided by MGI
    Primary source
    MGI:MGI:2685812
    See related
    Ensembl:ENSMUSG00000101031 AllianceGenome:MGI:2685812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm966
    Summary
    Predicted to be involved in cell surface receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human MS4A12 (membrane spanning 4-domains A12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 12.0), duodenum adult (RPKM 6.3) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ms4a12 in Genome Data Viewer
    Location:
    19 A; 19 8.07 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (11191392..11209846, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (11214028..11232482, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45565 Neighboring gene membrane-spanning 4-domains, subfamily A, member 19 Neighboring gene membrane-spanning 4-domains, subfamily A, member 13 Neighboring gene RIKEN cDNA 4930526L06 gene Neighboring gene STARR-seq mESC enhancer starr_45566 Neighboring gene STARR-seq mESC enhancer starr_45567 Neighboring gene STARR-positive B cell enhancer ABC_E11022 Neighboring gene membrane-spanning 4-domains, subfamily A, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E3243 Neighboring gene membrane-spanning 4-domains, subfamily A, member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    membrane-spanning 4-domains subfamily A member 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374133.1 → NP_001361062.1  membrane-spanning 4-domains subfamily A member 12

      Status: VALIDATED

      Source sequence(s)
      AC134839
      UniProtKB/TrEMBL
      A0A087WSB9
      Related
      ENSMUSP00000140981.2, ENSMUST00000186228.3
      Conserved Domains (1) summary
      pfam04103
      Location:85 → 218
      CD20; CD20-like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      11191392..11209846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247414.1 → XP_011245716.1  membrane-spanning 4-domains subfamily A member 12 isoform X3

      See identical proteins and their annotated locations for XP_011245716.1

    2. XM_006527507.1 → XP_006527570.1  membrane-spanning 4-domains subfamily A member 12 isoform X2

      See identical proteins and their annotated locations for XP_006527570.1

    3. XM_006527506.1 → XP_006527569.1  membrane-spanning 4-domains subfamily A member 12 isoform X1

      See identical proteins and their annotated locations for XP_006527569.1

      Conserved Domains (1) summary
      pfam04103
      Location:85 → 175
      CD20; CD20-like family
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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