U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Itga8 integrin alpha 8 [ Mus musculus (house mouse) ]

    Gene ID: 241226, updated on 4-Jan-2025

    Summary

    Official Symbol
    Itga8provided by MGI
    Official Full Name
    integrin alpha 8provided by MGI
    Primary source
    MGI:MGI:109442
    See related
    Ensembl:ENSMUSG00000026768 AllianceGenome:MGI:109442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded protein undergoes proteolytic processing to generate the disulfide-linked heterodimeric alpha subunit which, in turn associates with a beta subunit to form the functional integrin receptor. Mice lacking the encoded protein mostly die after birth due to kidney defects, but some of animals that survive exhibit defects in the sensory hair cells of the inner ear. [provided by RefSeq, Aug 2016]
    Expression
    Biased expression in lung adult (RPKM 16.4), bladder adult (RPKM 4.7) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Itga8 in Genome Data Viewer
    Location:
    2 A1; 2 9.12 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (12111443..12306755, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (12106632..12301985, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain-containing protein 20A12 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03681 Neighboring gene STARR-seq mESC enhancer starr_03682 Neighboring gene VISTA enhancer mm30 Neighboring gene STARR-seq mESC enhancer starr_03683 Neighboring gene karyopherin (importin) alpha 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03684 Neighboring gene STARR-seq mESC enhancer starr_03685 Neighboring gene STARR-seq mESC enhancer starr_03686 Neighboring gene STARR-seq mESC enhancer starr_03687 Neighboring gene STARR-seq mESC enhancer starr_03688 Neighboring gene STARR-seq mESC enhancer starr_03689 Neighboring gene RIKEN cDNA E030013I19 gene Neighboring gene STARR-seq mESC enhancer starr_03690 Neighboring gene MINDY lysine 48 deubiquitinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E5886 Neighboring gene predicted gene 13321

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables integrin binding  
    enables metal ion binding  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin  
    acts_upstream_of_or_within cell projection organization PubMed 
    involved_in cell-cell adhesion  
    involved_in cell-matrix adhesion  
    involved_in cell-matrix adhesion  
    involved_in cell-matrix adhesion  
    involved_in establishment of protein localization PubMed 
    acts_upstream_of_or_within extracellular matrix organization PubMed 
    acts_upstream_of_or_within inner ear morphogenesis PubMed 
    involved_in integrin-mediated signaling pathway  
    involved_in integrin-mediated signaling pathway  
    involved_in kidney development  
    acts_upstream_of_or_within memory PubMed 
    involved_in mesodermal cell differentiation  
    acts_upstream_of_or_within metanephros development PubMed 
    acts_upstream_of_or_within metanephros development PubMed 
    involved_in nervous system development  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway PubMed 
    acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway PubMed 
    involved_in smooth muscle cell differentiation PubMed 
    involved_in smooth muscle tissue development PubMed 
    involved_in substrate adhesion-dependent cell spreading  
    involved_in substrate adhesion-dependent cell spreading  
    acts_upstream_of transforming growth factor beta receptor signaling pathway PubMed 
    acts_upstream_of transforming growth factor beta receptor signaling pathway PubMed 
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    located_in apical part of cell PubMed 
    located_in cell surface  
    located_in cell surface  
    located_in dendritic spine membrane  
    located_in dendritic spine membrane  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    is_active_in external side of plasma membrane  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    part_of integrin complex  
    part_of integrin complex  
    located_in perikaryon  
    located_in perikaryon  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynaptic density membrane  
    is_active_in postsynaptic density membrane  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001309.4NP_001001309.1  integrin alpha-8 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001001309.1

      Status: REVIEWED

      Source sequence(s)
      AL845313
      Consensus CDS
      CCDS15689.1
      UniProtKB/Swiss-Prot
      A2ARA8, O70304, Q3UXV8, Q8BRG3, Q8C0H7
      Related
      ENSMUSP00000028106.5, ENSMUST00000028106.11
      Conserved Domains (3) summary
      smart00191
      Location:382436
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam00357
      Location:10341048
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:482933
      Integrin_alpha2; Integrin alpha
    2. NM_001408100.1NP_001395029.1  integrin alpha-8 isoform 2 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AL845313
    3. NM_001408101.1NP_001395030.1  integrin alpha-8 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AL845313
    4. NM_001408102.1NP_001395031.1  integrin alpha-8 isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AL845313

    RNA

    1. NR_138462.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AK033007, AK044910, AL845313, BC137793, BQ175493
      Related
      ENSMUST00000172791.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      12111443..12306755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497476.4XP_006497539.1  integrin alpha-8 isoform X2

      Conserved Domains (2) summary
      pfam00357
      Location:592606
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:23474
      Integrin_alpha2; Integrin alpha
    External link. Please review our privacy policy.