Ctbp1 C-terminal binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctbp1provided by RGD
Official Full Name: C-terminal binding protein 1provided by RGD
Primary source: RGD:2441
See related: EnsemblRapid:ENSRNOG00000005428 AllianceGenome:RGD:2441
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bars; BARS-50; CtBP3/BARS; 50-kDaBFA-inducedADP-ribosylatedsubstrate
Summary: Enables NAD binding activity; PDZ domain binding activity; and protein homodimerization activity. Involved in presynapse to nucleus signaling pathway. Located in cytoplasm and nucleus. Is active in glutamatergic synapse. Is extrinsic component of presynaptic endocytic zone membrane. Orthologous to human CTBP1 (C-terminal binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 462.1), Muscle (RPKM 461.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (81679956..81707331)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (77455580..77482821)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (82762109..82789350)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CTBP1 Confers Protection for Hippocampal and Cortical Neurons in Rat Models of Alzheimer's Disease.
Title: CTBP1 Confers Protection for Hippocampal and Cortical Neurons in Rat Models of Alzheimer's Disease.
Results shed light on the binding of CtBP1 protein to SUMOylated Foxp1 to repress the genetic transcription and drive dendritic morphogenesis.
Title: SUMOylation of FOXP1 regulates transcriptional repression via CtBP1 to drive dendritic morphogenesis.
CtBP1 is targeted and/or anchored to presynapses by direct interaction with the active zone scaffolding proteins Bassoon and piccolo.
Title: Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.
caspase-dependent downregulation of CtBP1 is sufficient to cause neuronal apoptosis.
Title: C-terminal binding proteins are essential pro-survival factors that undergo caspase-dependent downregulation during neuronal apoptosis.
The results presented shed first light on the correlation between NAD(H)-binding and functional CtBP1 dimerization
Title: CtBP1/BARS Gly172-->Glu mutant structure: impairing NAD(H)-binding and dimerization.
crystal structure of CtBP/BARS; structure together with mutagenesis data and binding experiments suggest a rationale for the molecular mechanisms underlying the two co-existing activities supported by CtBP/BARS in the nucleus and Golgi membranes
Title: CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission.
responsible for driving the fission of Golgi membranes during mitosis in vivo; BARS-induced fission of Golgi membranes controlled the G2-to-prophase transition of the cell cycle, and hence cell division
Title: Mitotic Golgi partitioning is driven by the membrane-fissioning protein CtBP3/BARS.
Interaction with CtBP was shown to be important in the repression of transcription by EBNA3A and in the ability of EBNA3A to immortalize and transform primary cells
Title: Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP).
CtBp proteins repress transcription in a histone deacetylase dependent or independent manner.
Title: CtBP, an unconventional transcriptional corepressor in development and oncogenesis.
Brefeldin A-ADP ribosylated substrate (BARS) is a newly discovered enzyme involved in membrane fission, catalyzing the formation of phosphatidic acid by transfer of an acyl group from acyl-CoA to lysophosphatidic acid.
Title: Crystallization and preliminary X-ray diffraction analysis of brefeldin A-ADP ribosylated substrate (BARS).

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables NAD binding	IDA Inferred from Direct Assay more info	PubMed
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	TAS Traceable Author Statement more info	PubMed
enables transcription corepressor binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in membrane fusion	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in presynapse to nucleus signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in presynapse to nucleus signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle clustering	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle clustering	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in white fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in white fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in white fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in extrinsic component of presynaptic endocytic zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in presynaptic active zone cytoplasmic component	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone cytoplasmic component	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	IEA Inferred from Electronic Annotation more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: C-terminal-binding protein 1

Names: 50 kDa BFA-dependent ADP-ribosylation substrate; 50-kDa BFA-induced ADP-ribosylated substrate; C-terminal-binding protein 3; C-terminus binding protein 3/brefeldin A (BFA) adenosine diphosphate-ribosylated substrate; brefeldin A-ADP-riboslyated substrate; ctBP3

NP_062074.2

EC 1.1.1.-

XP_006251287.1

EC 1.1.1.-

XP_006251288.1

EC 1.1.1.-

XP_006251289.1

EC 1.1.1.-

XP_006251290.1

EC 1.1.1.-

XP_017454636.1

EC 1.1.1.-

XP_063129063.1

EC 1.1.1.-

XP_063129064.1

EC 1.1.1.-

XP_063129066.1

EC 1.1.1.-

XP_063129067.1

EC 1.1.1.-

XP_063129068.1

EC 1.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019201.3 → NP_062074.2 C-terminal-binding protein 1

See identical proteins and their annotated locations for NP_062074.2

Status: PROVISIONAL

Source sequence(s)

AF067795

UniProtKB/Swiss-Prot

Q9Z2F5

UniProtKB/TrEMBL

A0A8I5ZSG1, A6IK67

Conserved Domains (1) summary

cd05299
Location:17 → 335

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

81679956..81707331

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251225.5 → XP_006251287.1 C-terminal-binding protein 1 isoform X1

UniProtKB/TrEMBL

A0A0H2UI20, A0A8I5ZSG1

Related

ENSRNOP00000054738.5, ENSRNOT00000057929.6

Conserved Domains (1) summary

cd05299
Location:28 → 346

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
XM_006251227.5 → XP_006251289.1 C-terminal-binding protein 1 isoform X5

UniProtKB/TrEMBL

A0A8I5ZSG1

Conserved Domains (1) summary

cd05299
Location:28 → 346

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
XM_006251226.5 → XP_006251288.1 C-terminal-binding protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I5ZSG1

Conserved Domains (1) summary

cd05299
Location:28 → 346

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
XM_006251228.5 → XP_006251290.1 C-terminal-binding protein 1 isoform X6

UniProtKB/TrEMBL

A0A8I5ZSG1

Conserved Domains (1) summary

cd05299
Location:28 → 346

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
XM_017599147.3 → XP_017454636.1 C-terminal-binding protein 1 isoform X3

UniProtKB/Swiss-Prot

Q9Z2F5

UniProtKB/TrEMBL

A0A8I5ZSG1, A6IK67

Conserved Domains (1) summary

cd05299
Location:17 → 335

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
XM_063272994.1 → XP_063129064.1 C-terminal-binding protein 1 isoform X4
XM_063272998.1 → XP_063129068.1 C-terminal-binding protein 1 isoform X8

UniProtKB/TrEMBL

Q6AZ26
XM_063272997.1 → XP_063129067.1 C-terminal-binding protein 1 isoform X7

UniProtKB/TrEMBL

F7FG31

Related

ENSRNOP00000080240.2, ENSRNOT00000112665.2
XM_063272993.1 → XP_063129063.1 C-terminal-binding protein 1 isoform X3

UniProtKB/Swiss-Prot

Q9Z2F5

UniProtKB/TrEMBL

A6IK67
XM_063272996.1 → XP_063129066.1 C-terminal-binding protein 1 isoform X4

Related

ENSRNOP00000081185.2, ENSRNOT00000119292.2