Mir190a microRNA 190a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mir190aprovided by MGI
Official Full Name: microRNA 190aprovided by MGI
Primary source: MGI:MGI:2676854
See related: Ensembl:ENSMUSG00000076379 miRBase:MI0000232; AllianceGenome:MGI:2676854
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mir190; Mirn190; mir-190; mir-190a; mmu-mir-190; mmu-mir-190a
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 9 C; 9 36.4 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (67143942..67144008, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (67236660..67236726, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-190 ameliorates glucotoxicity-induced dysfunction and apoptosis of pancreatic beta-cells by inhibiting NOX2-mediated reactive oxygen species production.
Title: MiR-190 ameliorates glucotoxicity-induced dysfunction and apoptosis of pancreatic β-cells by inhibiting NOX2-mediated reactive oxygen species production.
CircRNA_45478 promotes ischemic AKI by targeting the miR-190a-5p/PHLPP1 axis.
Title: CircRNA_45478 promotes ischemic AKI by targeting the miR-190a-5p/PHLPP1 axis.
Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis.
Title: Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis.
miR-190 alleviates neuronal damage and inhibits inflammation via negatively regulating the expression and activation of Nlrp3 in MPTP-induced Parkinson disease mouse model.
Title: MicroRNA-190 alleviates neuronal damage and inhibits neuroinflammation via Nlrp3 in MPTP-induced Parkinson's disease mouse model.
MiR-190a potentially ameliorates postoperative cognitive dysfunction by regulating Tiam1
Title: MiR-190a potentially ameliorates postoperative cognitive dysfunction by regulating Tiam1.
Methylglyoxal exposure reduces the expression of miRNA-190a in mouse aortic endothelial cells.
Title: The role of miR-190a in methylglyoxal-induced insulin resistance in endothelial cells.
decrease in miR-190 expression resulted from the agonist-selective ERK phosphorylation
Title: mu-Opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD.

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General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.