Bag1 BCL2-associated athanogene 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bag1provided by MGI
Official Full Name: BCL2-associated athanogene 1provided by MGI
Primary source: MGI:MGI:108047
See related: Ensembl:ENSMUSG00000028416 AllianceGenome:MGI:108047
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BAG-1; Rap46
Summary: The oncogene Bcl2 encodes a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to Bcl2 protein and is referred to as Bcl2-associated athanogene. It enhances the anti-apoptotic effects of Bcl2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least two protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site and an alternative, downstream, AUG translation initiation site. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in stomach adult (RPKM 201.2), adrenal adult (RPKM 182.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 20.67 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (40936398..40948294, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (40936398..40948294, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion.
Title: Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion.
These results provide evidence for an emerging role of BAG-1M in the regulation of BACE1 expression and AD pathogenesis and that targeting the BAG-1M-NF-kappaB complex may provide a mechanism for inhibiting Abeta production and plaque formation.
Title: BAG-1M co-activates BACE1 transcription through NF-κB and accelerates Aβ production and memory deficit in Alzheimer's disease mouse model.
that BAG-1L over-expression protects against hypoxia/re-oxygenation injury, at least in part, by interacting with HSP70, and by accelerating the activation of PI3K/AKT pathways
Title: BAG-1L Protects SH-SY5Y Neuroblastoma Cells Against Hypoxia/Re-oxygenation Through Up-Regulating HSP70 and Activating PI3K/AKT Signaling Pathway.
These studies demonstrate for the first time the significance of BAG-1-mediated protein-protein interactions.
Title: Regulation of osteoblast development by Bcl-2-associated athanogene-1 (BAG-1).
The BAG-1 stabilizes F508del-CFTR by direct binding, probably competing out ubiquitin to partially avoid its proteasomal degradation.
Title: BAG-1 stabilizes mutant F508del-CFTR in a ubiquitin-like-domain-dependent manner.
The membrane form of heparin binding EGF-like growth factor (ProHB-EGF) is most likely able to trigger the nuclear translocation of BAG-1 in keeping its level high.
Title: Nuclear magnetic resonance structure of the cytoplasmic tail of heparin binding EGF-like growth factor (proHB-EGF-CT) complexed with the ubiquitin homology domain of Bcl-2-associated athanogene 1 from Mus musculus (mBAG-1-UBH).
Hemoxygenase 1 deficiency provoked diminished Bag-1 level upon LPS treatment
Title: HO-1 as modulator of the innate immune response in pregnancy.
this study first reported the solution structure of mBAG-1-UBH and the growth factor precursor-interacting motif on the protein.
Title: The NMR solution structure of the ubiquitin homology domain of Bcl-2-associated athanogene 1 (BAG-1-UBH) from Mus musculus.
Bag-1 proteins function as regulators of the action of selective transcription factors.
Title: Depletion of the cellular levels of Bag-1 proteins attenuates phorbol ester-induced downregulation of IκBα and nuclear accumulation of NF-κB.
These data suggest a role for BAG-1 in mechanisms of neurogenesis in the adult mouse brain.
Title: BAG-1 is preferentially expressed in neuronal precursor cells of the adult mouse brain and regulates their proliferation in vitro.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Bag1 (e-PCR), detects polymorphism
- UniSTS:141154

D4Mit195 (e-PCR), detects polymorphism
- UniSTS:129976

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adenyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables adenyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaperone cofactor-dependent protein refolding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of motor neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Schwann cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein localization to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BAG family molecular chaperone regulator 1

Names: Bcl-2-binding protein; bcl-2-associated athanogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001171739.1 → NP_001165210.1 BAG family molecular chaperone regulator 1 isoform 1S

See identical proteins and their annotated locations for NP_001165210.1

Status: REVIEWED

Description

Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longer isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG) start codon, while the shorter isoform (BAG-1S or p32) is derived from a downstream AUG start codon. The shorter isoform (1S) is represented in this RefSeq.

Source sequence(s)

AK009149, AK013611, BQ031093, CX225744

Consensus CDS

CCDS51139.1

UniProtKB/Swiss-Prot

Q60739

UniProtKB/TrEMBL

Q9CUY1

Related

ENSMUSP00000139864.2, ENSMUST00000191273.7

Conserved Domains (3) summary

smart00213
Location:21 → 94

UBQ; Ubiquitin homologues

smart00264
Location:133 → 200

BAG; BAG domains, present in regulator of Hsp70 proteins

cl00155
Location:18 → 94

UBQ; Ubiquitin-like proteins
NM_009736.3 → NP_033866.4 BAG family molecular chaperone regulator 1 isoform 1L

See identical proteins and their annotated locations for NP_033866.4

Status: REVIEWED

Description

Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longer isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG) start codon, while the shorter isoform (BAG-1S or p32) is derived from a downstream AUG start codon. The longer isoform (1L) is represented in this RefSeq.

Source sequence(s)

AK009149, AK013611, BQ031093, CX225744

Consensus CDS

CCDS38713.1

UniProtKB/Swiss-Prot

Q561N1, Q60739, Q6IS45, Q9D7K6

UniProtKB/TrEMBL

F6TCF9

Related

ENSMUSP00000030125.5, ENSMUST00000030125.5

Conserved Domains (3) summary

smart00213
Location:157 → 230

UBQ; Ubiquitin homologues

smart00264
Location:269 → 336

BAG; BAG domains, present in regulator of Hsp70 proteins

cl00155
Location:154 → 230

UBQ; Ubiquitin-like proteins