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    Cdkn2c cyclin dependent kinase inhibitor 2C [ Mus musculus (house mouse) ]

    Gene ID: 12580, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdkn2cprovided by MGI
    Official Full Name
    cyclin dependent kinase inhibitor 2Cprovided by MGI
    Primary source
    MGI:MGI:105388
    See related
    Ensembl:ENSMUSG00000028551 AllianceGenome:MGI:105388
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p18; INK4c; p18-INK6; p18INK4c; p18-INK4c
    Summary
    The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase (cdk) inhibitors, and contains five ankyrin repeats. This protein interacts with both Cdk4 and Cdk6 to inhibit their kinase activities, and prevent their interactions with D-type cyclins, thereby negatively regulating cell division. This gene is differentially expressed in a variety of tissues, and is cell cycle regulated. Deletion of this gene can lead to tumor growth. Maximal expression is observed at the G2/M phase. Alternative splicing and promoter usage results in multiple transript variants. [provided by RefSeq, Aug 2014]
    Expression
    Broad expression in testis adult (RPKM 24.9), subcutaneous fat pad adult (RPKM 21.7) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cdkn2c in Genome Data Viewer
    Location:
    4 C7; 4 51.32 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (109518073..109523953, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (109660876..109666756, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9630013D21 gene Neighboring gene predicted gene, 40227 Neighboring gene Fas-associated factor 1 Neighboring gene STARR-seq mESC enhancer starr_11075 Neighboring gene STARR-seq mESC enhancer starr_11076 Neighboring gene doublesex and mab-3 related transcription factor like family A2, opposite strand Neighboring gene doublesex and mab-3 related transcription factor like family A2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase 4 inhibitor C
    Names
    cyclin-dependent kinase 6 inhibitor
    cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301368.2NP_001288297.1  cyclin-dependent kinase 4 inhibitor C

      See identical proteins and their annotated locations for NP_001288297.1

      Status: VALIDATED

      Source sequence(s)
      AL627264, AL627392
      Consensus CDS
      CCDS18467.1
      UniProtKB/Swiss-Prot
      Q60772
      UniProtKB/TrEMBL
      Q3U054, Q9D153
      Related
      ENSMUSP00000095534.4, ENSMUST00000097921.10
      Conserved Domains (2) summary
      cd00204
      Location:37156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:3767
      ANK; ANK repeat [structural motif]
    2. NM_007671.4NP_031697.1  cyclin-dependent kinase 4 inhibitor C

      See identical proteins and their annotated locations for NP_031697.1

      Status: VALIDATED

      Source sequence(s)
      AL627264, AL627392
      Consensus CDS
      CCDS18467.1
      UniProtKB/Swiss-Prot
      Q60772
      UniProtKB/TrEMBL
      Q3U054, Q9D153
      Related
      ENSMUSP00000070313.5, ENSMUST00000063531.5
      Conserved Domains (2) summary
      cd00204
      Location:37156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:3767
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      109518073..109523953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)