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    Zp3r zona pellucida 3 receptor [ Mus musculus (house mouse) ]

    Gene ID: 22789, updated on 3-Dec-2024

    Summary

    Official Symbol
    Zp3rprovided by MGI
    Official Full Name
    zona pellucida 3 receptorprovided by MGI
    Primary source
    MGI:MGI:104965
    See related
    Ensembl:ENSMUSG00000042554 AllianceGenome:MGI:104965
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SP56
    Summary
    Involved in binding activity of sperm to zona pellucida. Acts upstream of or within single fertilization. Located in acrosomal vesicle; cell body; and plasma membrane. Part of zona pellucida receptor complex. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4BPA (complement component 4 binding protein alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 24.4) See more
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    Genomic context

    See Zp3r in Genome Data Viewer
    Location:
    1 E4; 1 56.89 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130474847..130557371, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130547110..130629634, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CD55 molecule, decay accelerating factor for complement B Neighboring gene CD55 molecule, opposite strand sequence Neighboring gene CD55 molecule, decay accelerating factor for complement Neighboring gene STARR-positive B cell enhancer ABC_E9183 Neighboring gene STARR-positive B cell enhancer ABC_E7745 Neighboring gene STARR-seq mESC enhancer starr_02195 Neighboring gene predicted gene 16083 Neighboring gene STARR-positive B cell enhancer ABC_E11084 Neighboring gene STARR-seq mESC enhancer starr_02198 Neighboring gene STARR-positive B cell enhancer mm9_chr1:132472703-132473004 Neighboring gene STARR-seq mESC enhancer starr_02199 Neighboring gene predicted gene, 23623 Neighboring gene STARR-seq mESC enhancer starr_02200 Neighboring gene complement component 4 binding protein Neighboring gene complement component 4 binding protein, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in acrosomal matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in acrosomal matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in acrosomal vesicle EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in outer acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of zona pellucida receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zona pellucida sperm-binding protein 3 receptor
    Names
    sperm fertilization protein 56

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420657.1NP_001407586.1  zona pellucida sperm-binding protein 3 receptor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC109283, AC122773
      UniProtKB/Swiss-Prot
      Q60736
      UniProtKB/TrEMBL
      Q0VET1
      Related
      ENSMUSP00000114401.2, ENSMUST00000128128.8
    2. NM_009581.3NP_033607.2  zona pellucida sperm-binding protein 3 receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_033607.2

      Status: VALIDATED

      Source sequence(s)
      AC109283, AC122773
      Consensus CDS
      CCDS15257.1
      UniProtKB/Swiss-Prot
      Q60736
      UniProtKB/TrEMBL
      G3X970, Q0VET1
      Related
      ENSMUSP00000045443.5, ENSMUST00000039862.11
      Conserved Domains (4) summary
      cd00033
      Location:158219
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:350411
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:153411
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:283343
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      130474847..130557371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247992.3XP_011246294.1  zona pellucida sperm-binding protein 3 receptor isoform X2

      Conserved Domains (3) summary
      smart00032
      Location:371432
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:71299
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:304364
      Sushi; Sushi repeat (SCR repeat)