Gcgr glucagon receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gcgrprovided by RGD
Official Full Name: glucagon receptorprovided by RGD
Primary source: RGD:2669
See related: EnsemblRapid:ENSRNOG00000036692 AllianceGenome:RGD:2669
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables glucagon receptor activity and peptide hormone binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; exocytosis; and hormone-mediated signaling pathway. Located in endosome. Human ortholog(s) of this gene implicated in Mahvash Disease and type 2 diabetes mellitus. Orthologous to human GCGR (glucagon receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 206.9), Kidney (RPKM 67.8) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (106306803..106314970)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (105808474..105816641)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (109707863..109716253)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The vasodilatation due to glucagon evokes via the glucagon-receptor, but also via the receptor for GLP-1, and it is endothelium-independent.
Title: Vasodilator Effect of Glucagon: Receptorial Crosstalk Among Glucagon, GLP-1, and Receptor for Glucagon and GLP-1.
Significant higher GluR density (mRNA and proteins) following exercise and fasting than in the control group.
Title: Liver glucagon receptors (GluR): effect of exercise and fasting on binding characteristics, GluR-mRNA, and GluR protein content in rats.
The actin cytoskeleton, beta-arrestin1, beta-arrestin2, and the glucagon receptor's carboxyl terminus are involved in its recycling.
Title: Glucagon receptor recycling: role of carboxyl terminus, beta-arrestins, and cytoskeleton.
These results suggest that glucagon stimulates acute release of both forms of ghrelin and thereafter upregulates synthesis and release of desacyl-ghrelin in the rat stomach.
Title: Glucagon receptor expression and glucagon stimulation of ghrelin secretion in rat stomach.
Gln(3) residue of glucagon did not interact with the equivalent binding pocket as the Asp(3) residue of vasoactive intestinal peptide or secretin
Title: Mutational analysis of the glucagon receptor: similarities with the vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase-activating peptide (PACAP)/secretin receptors for recognition of the ligand's third residue.
The present results indicate that the feeding of an HF diet is associated with a reduction in plasma membrane hepatic glucagon receptor density and G(s)alpha protein content, which is not attenuated by a 30-min exercise bout.
Title: Alterations in hepatic glucagon receptor density and in Gsalpha and Gialpha2 protein content with diet-induced hepatic steatosis: effects of acute exercise.
within hepatic target cells and consequent to glucagon-mediated internalization of the serine-phosphorylated glucagon receptor and the Gsalpha protein, extended signal transduction may occur in vivo at the locus of the endo-lysosomal apparatus
Title: Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver.
A model is proposed for glucagon receptor activation whereby glucagon first interacts with the receptor N-terminal domain followed by more specific interactions between the N-terminal half of the peptide and the first extracellular loop of the receptor.
Title: Roles of specific extracellular domains of the glucagon receptor in ligand binding and signaling.
glucagon were unaffected by the GLP-1 receptor antagonist exendin-(9-39) but abolished by des-His1-[Glu9]-glucagon-amide, a specific blocker of the glucagon receptor
Title: Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.
High fat diet induced obesity is associated with a desensitization and destruction of the hepatic GR
Title: High-fat diet-induced hepatic steatosis reduces glucagon receptor content in rat hepatocytes: potential interaction with acute exercise.

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General gene information

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Markers

Gcgr (e-PCR), detects polymorphism
- UniSTS:257076

D10Mcw1 (e-PCR)
- UniSTS:240483

RH141343 (e-PCR)
- UniSTS:223339

RH142644 (e-PCR)
- UniSTS:231891

RH142648 (e-PCR)
- UniSTS:231895

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glucagon receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucagon receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables glucagon receptor activity	IEA Inferred from Electronic Annotation more info
enables glucagon receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glucagon receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide hormone binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucagon stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucagon stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in hormone-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in hormone-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of glycogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of glycogen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to starvation	ISO Inferred from Sequence Orthology more info
involved_in response to starvation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glucagon receptor

Names: GL-R; glucagon receptor perhaps same as Niddm3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430043.1 → NP_001416972.1 glucagon receptor isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_001430044.1 → NP_001416973.1 glucagon receptor isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_001430045.1 → NP_001416974.1 glucagon receptor isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_172091.3 → NP_742088.1 glucagon receptor isoform a precursor

See identical proteins and their annotated locations for NP_742088.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal non-coding exon, therefore, has a different 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P30082

UniProtKB/TrEMBL

A6HLE4

Conserved Domains (2) summary

cd15267
Location:137 → 418

7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:56 → 123

HRM; Hormone receptor domain
NM_172092.3 → NP_742089.1 glucagon receptor isoform a precursor

See identical proteins and their annotated locations for NP_742089.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P30082

UniProtKB/TrEMBL

A6HLE4

Related

ENSRNOP00000107799.1, ENSRNOT00000153208.1

Conserved Domains (2) summary

cd15267
Location:137 → 418

7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:56 → 123

HRM; Hormone receptor domain

RNA

NR_073147.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

JAXUCZ010000010

Related

ENSRNOT00000088898.3
NR_190841.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

106306803..106314970

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008768468.4 → XP_008766690.1 glucagon receptor isoform X1

Conserved Domains (2) summary

pfam00002
Location:144 → 380

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:61 → 128

HRM; Hormone receptor domain
XM_008768469.4 → XP_008766691.1 glucagon receptor isoform X3

Conserved Domains (2) summary

pfam00002
Location:144 → 380

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:61 → 128

HRM; Hormone receptor domain
XM_039085247.2 → XP_038941175.1 glucagon receptor isoform X6

Conserved Domains (3) summary

pfam02793
Location:61 → 128

HRM; Hormone receptor domain

cd14964
Location:146 → 171

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:142 → 299

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039085243.2 → XP_038941171.1 glucagon receptor isoform X2

UniProtKB/Swiss-Prot

P30082

UniProtKB/TrEMBL

A6HLE4

Conserved Domains (2) summary

cd15267
Location:137 → 418

7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:56 → 123

HRM; Hormone receptor domain
XM_006247877.3 → XP_006247939.1 glucagon receptor isoform X4

Related

ENSRNOP00000051845.2, ENSRNOT00000054962.4

Conserved Domains (1) summary

pfam00002
Location:103 → 339

7tm_2; 7 transmembrane receptor (Secretin family)
XM_039085245.2 → XP_038941173.1 glucagon receptor isoform X5

UniProtKB/TrEMBL

Q66HT0

Conserved Domains (1) summary

cd15267
Location:26 → 307

7tmB1_GCGR; glucagon receptor, member of the class B family of seven-transmembrane G protein-coupled receptors