Sgk2 serum/glucocorticoid regulated kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sgk2provided by MGI
Official Full Name: serum/glucocorticoid regulated kinase 2provided by MGI
Primary source: MGI:MGI:1351318
See related: Ensembl:ENSMUSG00000017868 AllianceGenome:MGI:1351318
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sgkl
Summary: Predicted to enable potassium channel regulator activity and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in nucleoplasm. Orthologous to human SGK2 (serum/glucocorticoid regulated kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney adult (RPKM 26.4), liver adult (RPKM 9.0) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H2; 2 83.93 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (162829249..162856059)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (162987327..163014139)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VRK1 self-represses its activity to phosphorylate PXR through cyclin-dependent kinase 2 (CDK2) in high glucose conditions, resulting in the repression of the PCK1 gene. This PXR phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2-PXR-PP2Calpha-SGK2 pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose.
Title: Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal.
the nucleotide substitution in the Sgkl gene is the causative mutation for defective hair growth in the ypc mutant mouse and the signaling pathway involving SGKL plays an essential role in mammalian hair development
Title: A mutation in the serum and glucocorticoid-inducible kinase-like kinase (Sgkl) gene is associated with defective hair growth in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

AW146006 (e-PCR)
- UniSTS:178762

AI098171 (e-PCR)
- UniSTS:159068

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase Sgk2

NP_001278081.1

EC 2.7.11.1

NP_001278083.1

EC 2.7.11.1

NP_038759.1

EC 2.7.11.1

XP_006499721.1

EC 2.7.11.1

XP_006499723.1

EC 2.7.11.1

XP_011237882.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291152.1 → NP_001278081.1 serine/threonine-protein kinase Sgk2 isoform b

See identical proteins and their annotated locations for NP_001278081.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a. The 5' UTR of this variant is incomplete due to lack of a complete transcript and splice pattern ambiguity in the upstream region.

Source sequence(s)

AK050009, AK136559, AV370098, BB350718

UniProtKB/TrEMBL

Q3UW73

Conserved Domains (2) summary

smart00220
Location:35 → 291

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:39 → 358

PKc_like; Protein Kinases, catalytic domain
NM_001291154.1 → NP_001278083.1 serine/threonine-protein kinase Sgk2 isoform c

See identical proteins and their annotated locations for NP_001278083.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AI747981, AK050009, AL591584, AV370098, BB350718

Consensus CDS

CCDS71184.1

UniProtKB/TrEMBL

Q3UW73

Related

ENSMUSP00000112468.2, ENSMUST00000117123.2

Conserved Domains (1) summary

cl21453
Location:39 → 330

PKc_like; Protein Kinases, catalytic domain
NM_013731.3 → NP_038759.1 serine/threonine-protein kinase Sgk2 isoform a

See identical proteins and their annotated locations for NP_038759.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AI747981, AK050009, AK136559, AV370098, BB350718

Consensus CDS

CCDS17004.1

UniProtKB/Swiss-Prot

B7ZC31, Q8R0P6, Q9QZS5

UniProtKB/TrEMBL

Q3UW73

Related

ENSMUSP00000018012.8, ENSMUST00000018012.14

Conserved Domains (1) summary

cl21453
Location:39 → 359

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

162829249..162856059

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499660.5 → XP_006499723.1 serine/threonine-protein kinase Sgk2 isoform X3

Conserved Domains (1) summary

cl21453
Location:39 → 283

PKc_like; Protein Kinases, catalytic domain
XM_011239580.3 → XP_011237882.1 serine/threonine-protein kinase Sgk2 isoform X2

See identical proteins and their annotated locations for XP_011237882.1

UniProtKB/TrEMBL

Q3UW73

Conserved Domains (1) summary

cl21453
Location:39 → 330

PKc_like; Protein Kinases, catalytic domain
XM_006499658.5 → XP_006499721.1 serine/threonine-protein kinase Sgk2 isoform X1

See identical proteins and their annotated locations for XP_006499721.1

UniProtKB/Swiss-Prot

B7ZC31, Q8R0P6, Q9QZS5

UniProtKB/TrEMBL

Q3UW73

Conserved Domains (1) summary

cl21453
Location:39 → 359

PKc_like; Protein Kinases, catalytic domain