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    Sit1 suppression inducing transmembrane adaptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 54390, updated on 27-Nov-2024

    Summary

    Official Symbol
    Sit1provided by MGI
    Official Full Name
    suppression inducing transmembrane adaptor 1provided by MGI
    Primary source
    MGI:MGI:1889342
    See related
    Ensembl:ENSMUSG00000028460 AllianceGenome:MGI:1889342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sit
    Summary
    Predicted to enable kinase binding activity. Predicted to be involved in regulation of T cell activation. Predicted to be active in plasma membrane. Orthologous to human SIT1 (signaling threshold regulating transmembrane adaptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 61.9), spleen adult (RPKM 7.1) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Sit1 in Genome Data Viewer
    Location:
    4 A5; 4 23.04 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43482083..43483709, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43482083..43483709, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RUN and SH3 domain containing 2 Neighboring gene ciliary microtubule inner protein 2B Neighboring gene testis specific protein kinase 1 Neighboring gene CD72 antigen Neighboring gene STARR-positive B cell enhancer ABC_E2109 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:43495064-43495217 Neighboring gene STARR-positive B cell enhancer ABC_E834 Neighboring gene coiled-coil domain containing 107 Neighboring gene RNA component of mitochondrial RNAase P

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in T cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    signaling threshold-regulating transmembrane adapter 1
    Names
    SHP2 interacting transmembrane adaptor protein
    SHP2-interacting transmembrane adapter protein
    suppression-inducing transmembrane adapter 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019436.3NP_062309.2  signaling threshold-regulating transmembrane adapter 1

      See identical proteins and their annotated locations for NP_062309.2

      Status: VALIDATED

      Source sequence(s)
      BC064055
      Consensus CDS
      CCDS18096.1
      UniProtKB/Swiss-Prot
      Q8C503, Q9WUU5
      Related
      ENSMUSP00000030180.7, ENSMUST00000030180.7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      43482083..43483709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)