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    Galnt6 polypeptide N-acetylgalactosaminyltransferase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361647, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Galnt6provided by RGD
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 6provided by RGD
    Primary source
    RGD:2319726
    See related
    EnsemblRapid:ENSRNOG00000033059 AllianceGenome:RGD:2319726
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via threonine. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Orthologous to human GALNT6 (polypeptide N-acetylgalactosaminyltransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 66.0), Thymus (RPKM 63.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Galnt6 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (133668612..133715909, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (131789836..131828077, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142322172..142364281, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene bridging integrator 2 Neighboring gene uncharacterized LOC134479578 Neighboring gene chymotrypsin like elastase 1 Neighboring gene solute carrier family 4 member 8 Neighboring gene uncharacterized LOC134479785

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy. Bennett EP, et al. J Biol Chem, 1999 Sep 3. PMID 10464263
    2. The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization. Argüeso P, et al. Invest Ophthalmol Vis Sci, 2003 Jan. PMID 12506059
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation via threonine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 6
    Names
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
    NP_001165534.1
    XP_006242357.1
    XP_006242358.1
    XP_008763873.1
    XP_038934161.1
    XP_063118905.1
    XP_063118906.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172063.2 → NP_001165534.1  polypeptide N-acetylgalactosaminyltransferase 6

      See identical proteins and their annotated locations for NP_001165534.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      D4A864
      Conserved Domains (2) summary
      cd02510
      Location:180 → 485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497 → 619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      133668612..133715909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262835.1 → XP_063118905.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/TrEMBL
      D4A864

    2. XM_006242296.5 → XP_006242358.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      See identical proteins and their annotated locations for XP_006242358.1

      UniProtKB/TrEMBL
      D4A864
      Related
      ENSRNOP00000070003.1, ENSRNOT00000078848.3
      Conserved Domains (2) summary
      cd02510
      Location:180 → 485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497 → 619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    3. XM_039078233.2 → XP_038934161.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/TrEMBL
      D4A864
      Conserved Domains (2) summary
      cd02510
      Location:180 → 485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497 → 619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    4. XM_006242295.5 → XP_006242357.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      See identical proteins and their annotated locations for XP_006242357.1

      UniProtKB/TrEMBL
      D4A864
      Conserved Domains (2) summary
      cd02510
      Location:180 → 485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497 → 619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    5. XM_008765651.4 → XP_008763873.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      See identical proteins and their annotated locations for XP_008763873.1

      UniProtKB/TrEMBL
      D4A864
      Conserved Domains (2) summary
      cd02510
      Location:180 → 485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497 → 619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    6. XM_063262836.1 → XP_063118906.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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