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    Iigp1 interferon inducible GTPase 1 [ Mus musculus (house mouse) ]

    Gene ID: 60440, updated on 9-Dec-2024

    Summary

    Official Symbol
    Iigp1provided by MGI
    Official Full Name
    interferon inducible GTPase 1provided by MGI
    Primary source
    MGI:MGI:1926259
    See related
    Ensembl:ENSMUSG00000054072 AllianceGenome:MGI:1926259
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Iigp; Irga6; Ifgga1; 2900074L10Rik
    Summary
    Enables GTPase activity; guanyl ribonucleotide binding activity; and identical protein binding activity. Involved in defense response to Gram-negative bacterium; defense response to protozoan; and regulation of autophagy. Acts upstream of or within cellular response to interferon-beta and response to bacterium. Located in endoplasmic reticulum membrane and symbiont-containing vacuole membrane. Is active in cytoplasm. Is expressed in several structures, including foregut; genitourinary system; heart; limb; and respiratory system. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E18 (RPKM 22.2), liver adult (RPKM 9.9) and 4 other tissues See more
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    Genomic context

    See Iigp1 in Genome Data Viewer
    Location:
    18 D3; 18 34.36 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (60506688..60525706)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60373616..60392634)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene immunity-related GTPase pseudogene Neighboring gene interferon inducible GTPase 1 pseudogene Neighboring gene predicted pseudogene 6960 Neighboring gene interferon-inducible GTPase-like pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in symbiont-containing vacuole membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    interferon-inducible GTPase 1
    Names
    interferon-gamma-inducible GTPase Ifgga1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146275.1NP_001139747.1  interferon-inducible GTPase 1

      See identical proteins and their annotated locations for NP_001139747.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC151990, AF194871, AJ007971, AK153060, DV061261
      Consensus CDS
      CCDS29270.1
      UniProtKB/Swiss-Prot
      Q9QZ85, Q9Z1M3
      UniProtKB/TrEMBL
      J7NNX8, U5NG72
      Related
      ENSMUSP00000032473.7, ENSMUST00000032473.7
      Conserved Domains (1) summary
      pfam05049
      Location:35409
      IIGP; Interferon-inducible GTPase (IIGP)
    2. NM_021792.5NP_068564.4  interferon-inducible GTPase 1

      See identical proteins and their annotated locations for NP_068564.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC151990, AF194871, AJ007971, AK153060
      Consensus CDS
      CCDS29270.1
      UniProtKB/Swiss-Prot
      Q9QZ85, Q9Z1M3
      UniProtKB/TrEMBL
      J7NNX8, U5NG72
      Conserved Domains (1) summary
      pfam05049
      Location:35409
      IIGP; Interferon-inducible GTPase (IIGP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      60506688..60525706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246978.4XP_011245280.1  interferon-inducible GTPase 1 isoform X1

      See identical proteins and their annotated locations for XP_011245280.1

      UniProtKB/Swiss-Prot
      Q9QZ85, Q9Z1M3
      UniProtKB/TrEMBL
      J7NNX8, U5NG72
      Conserved Domains (1) summary
      pfam05049
      Location:35409
      IIGP; Interferon-inducible GTPase (IIGP)
    2. XM_011246980.3XP_011245282.1  interferon-inducible GTPase 1 isoform X1

      See identical proteins and their annotated locations for XP_011245282.1

      UniProtKB/Swiss-Prot
      Q9QZ85, Q9Z1M3
      UniProtKB/TrEMBL
      J7NNX8, U5NG72
      Conserved Domains (1) summary
      pfam05049
      Location:35409
      IIGP; Interferon-inducible GTPase (IIGP)
    3. XM_030250557.2XP_030106417.1  interferon-inducible GTPase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9QZ85, Q9Z1M3
      UniProtKB/TrEMBL
      J7NNX8, U5NG72
      Related
      ENSMUSP00000063390.6, ENSMUST00000066912.13
      Conserved Domains (1) summary
      pfam05049
      Location:35409
      IIGP; Interferon-inducible GTPase (IIGP)
    4. XM_011246979.4XP_011245281.1  interferon-inducible GTPase 1 isoform X1

      See identical proteins and their annotated locations for XP_011245281.1

      UniProtKB/Swiss-Prot
      Q9QZ85, Q9Z1M3
      UniProtKB/TrEMBL
      J7NNX8, U5NG72
      Conserved Domains (1) summary
      pfam05049
      Location:35409
      IIGP; Interferon-inducible GTPase (IIGP)
    5. XM_030250559.2XP_030106419.1  interferon-inducible GTPase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9QZ85, Q9Z1M3
      UniProtKB/TrEMBL
      J7NNX8, U5NG72
      Conserved Domains (1) summary
      pfam05049
      Location:35409
      IIGP; Interferon-inducible GTPase (IIGP)
    6. XM_036161227.1XP_036017120.1  interferon-inducible GTPase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9QZ85, Q9Z1M3
      UniProtKB/TrEMBL
      J7NNX8, U5NG72
      Related
      ENSMUSP00000157568.2, ENSMUST00000237185.2
      Conserved Domains (1) summary
      pfam05049
      Location:35409
      IIGP; Interferon-inducible GTPase (IIGP)