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    Ivns1abp influenza virus NS1A binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289089, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ivns1abpprovided by RGD
    Official Full Name
    influenza virus NS1A binding proteinprovided by RGD
    Primary source
    RGD:1306290
    See related
    EnsemblRapid:ENSRNOG00000002618 AllianceGenome:RGD:1306290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including negative regulation of protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to virus. Predicted to act upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Predicted to be located in cytosol and nucleus. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in immunodeficiency 70. Orthologous to human IVNS1ABP (influenza virus NS1A binding protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 1490.3), Heart (RPKM 837.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ivns1abp in Genome Data Viewer
    Location:
    13q21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (65977069..65996685)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (63427040..63446701)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (68702970..68722472)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134481568 Neighboring gene SWT1 RNA endoribonuclease homolog Neighboring gene tRNA methyltransferase 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. [Characteristics and expression of Mip5, a novel gene associated with myocardial ischemia/reperfusion in rats]. Wang JS, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2005 Oct. PMID 16320578
    2. Protective role of Nd1 in doxorubicin-induced cardiotoxicity. Fujimura L, et al. Cardiovasc Res, 2004 Nov 1. PMID 15485691
    3. Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1. Guazzi P, et al. PLoS One, 2012. PMID 22970292, Free PMC Article
    4. KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination. Chen HY, et al. Oncogene, 2015 Oct 1. PMID 25619834
    5. Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing. Tsai PL, et al. PLoS Pathog, 2013. PMID 23825951, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    influenza virus NS1A-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401342.1 → NP_001388271.1  influenza virus NS1A-binding protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6ICS0
      Related
      ENSRNOP00000003558.7, ENSRNOT00000003558.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      65977069..65996685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249989.5 → XP_006250051.1  influenza virus NS1A-binding protein isoform X2

      See identical proteins and their annotated locations for XP_006250051.1

      UniProtKB/TrEMBL
      A6ICS2, D4A0T2
      Conserved Domains (2) summary
      cd18306
      Location:14 → 137
      BTB_POZ_NS1BP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP)
      cd18502
      Location:129 → 221
      BACK_NS1BP_IVNS1ABP; BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP)

    2. XM_039090454.1 → XP_038946382.1  influenza virus NS1A-binding protein isoform X1

      Related
      ENSRNOP00000071484.2, ENSRNOT00000083301.3
      Conserved Domains (3) summary
      smart00612
      Location:151 → 197
      Kelch; Kelch domain
      PHA03098
      Location:199 → 420
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:235 → 280
      Kelch; KELCH repeat [structural motif]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047085.1: Suppressed sequence

      Description
      NM_001047085.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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