Zbtb7b zinc finger and BTB domain containing 7B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zbtb7bprovided by MGI
Official Full Name: zinc finger and BTB domain containing 7Bprovided by MGI
Primary source: MGI:MGI:102755
See related: Ensembl:ENSMUSG00000028042 AllianceGenome:MGI:102755
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Thpok; Zfp67; c-Krox
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of signal transduction; regulation of alpha-beta T cell activation; and regulation of gene expression. Acts upstream of or within regulation of alpha-beta T cell differentiation and regulation of gene expression. Located in nucleus. Is expressed in several structures, including alimentary system; early conceptus; forebrain; genitourinary system; and sensory organ. Orthologous to human ZBTB7B (zinc finger and BTB domain containing 7B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in colon adult (RPKM 66.4), duodenum adult (RPKM 59.2) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.09 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (89284953..89300976, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (89377644..89393673, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function.
Title: ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function.
ThPOK is a critical multifaceted regulator of myeloid lineage development.
Title: ThPOK is a critical multifaceted regulator of myeloid lineage development.
The Transcription Factor ThPOK Regulates ILC3 Lineage Homeostasis and Function During Intestinal Infection.
Title: The Transcription Factor ThPOK Regulates ILC3 Lineage Homeostasis and Function During Intestinal Infection.
Epigenetic DNA methylation of Zbtb7b regulates the population of double-positive CD4(+)CD8(+) T cells in ulcerative colitis.
Title: Epigenetic DNA methylation of Zbtb7b regulates the population of double-positive CD4(+)CD8(+) T cells in ulcerative colitis.
Twist2 promotes CD8(+) T-cell differentiation by repressing ThPOK expression.
Title: Twist2 promotes CD8(+) T-cell differentiation by repressing ThPOK expression.
Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.
Title: Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.
Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4(+) T cell identity and function.
Title: Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4(+) T cell identity and function.
A Fateful Decision in the Thymus Controlled by the Transcription Factor ThPOK.
Title: A Fateful Decision in the Thymus Controlled by the Transcription Factor ThPOK.
Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.
Title: Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.
Identified an R367Q mutation in the ZBTB7B (ThPOK) protein.
Title: ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3)
Spontaneous (1) 1 citation
Targeted (18) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NK T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adaptive thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lactation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of CD8-positive, alpha-beta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of NK T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T-helper 17 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of CD4-positive, alpha-beta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of SREBP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of brown fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-17 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of CD8-positive, alpha-beta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of T-helper cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to insulin	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 7B

Names: T-helper-inducing POZ/Krueppel-like factor; Vzinc finger and BTB domain containing 7B; krueppel-related zinc finger protein cKrox; zinc finger protein 67; zinc finger protein Th-POK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355206.2 → NP_001342135.2 zinc finger and BTB domain-containing protein 7B

Status: VALIDATED

Source sequence(s)

AC171273

UniProtKB/Swiss-Prot

Q64321, Q80VV5

UniProtKB/TrEMBL

Q5BJ24

Related

ENSMUSP00000103058.2, ENSMUST00000107435.8
NM_001355211.2 → NP_001342140.1 zinc finger and BTB domain-containing protein 7B

Status: VALIDATED

Source sequence(s)

AC171273

Consensus CDS

CCDS17504.1

UniProtKB/Swiss-Prot

Q64321, Q80VV5

UniProtKB/TrEMBL

Q5BJ24

Related

ENSMUSP00000103055.2, ENSMUST00000107432.8

Conserved Domains (4) summary

COG5048
Location:349 → 428

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:380 → 400

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18327
Location:9 → 142

BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)

pfam13465
Location:420 → 445

zf-H2C2_2; Zinc-finger double domain
NM_001355212.2 → NP_001342141.1 zinc finger and BTB domain-containing protein 7B

Status: VALIDATED

Source sequence(s)

AC171273

Consensus CDS

CCDS17504.1

UniProtKB/Swiss-Prot

Q64321, Q80VV5

UniProtKB/TrEMBL

Q5BJ24

Related

ENSMUSP00000103056.2, ENSMUST00000107433.8

Conserved Domains (4) summary

COG5048
Location:349 → 428

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:380 → 400

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18327
Location:9 → 142

BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)

pfam13465
Location:420 → 445

zf-H2C2_2; Zinc-finger double domain
NM_001410678.1 → NP_001397607.1 zinc finger and BTB domain-containing protein 7B

Status: VALIDATED

Source sequence(s)

AC171273

UniProtKB/Swiss-Prot

Q64321, Q80VV5

UniProtKB/TrEMBL

Q5BJ24
NM_001410679.1 → NP_001397608.1 zinc finger and BTB domain-containing protein 7B

Status: VALIDATED

Source sequence(s)

AC171273

UniProtKB/Swiss-Prot

Q64321, Q80VV5

UniProtKB/TrEMBL

Q5BJ24
NM_001410680.1 → NP_001397609.1 zinc finger and BTB domain-containing protein 7B

Status: VALIDATED

Source sequence(s)

AC171273

UniProtKB/Swiss-Prot

Q64321, Q80VV5

UniProtKB/TrEMBL

Q5BJ24
NM_001410681.1 → NP_001397610.1 zinc finger and BTB domain-containing protein 7B

Status: VALIDATED

Source sequence(s)

AC171273

UniProtKB/Swiss-Prot

Q64321, Q80VV5

UniProtKB/TrEMBL

Q5BJ24
NM_009565.6 → NP_033591.2 zinc finger and BTB domain-containing protein 7B

See identical proteins and their annotated locations for NP_033591.2

Status: VALIDATED

Source sequence(s)

AC171273

Consensus CDS

CCDS17504.1

UniProtKB/Swiss-Prot

Q64321, Q80VV5

UniProtKB/TrEMBL

Q5BJ24

Related

ENSMUSP00000029677.9, ENSMUST00000029677.9

Conserved Domains (4) summary

COG5048
Location:349 → 428

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:380 → 400

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18327
Location:9 → 142

BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)

pfam13465
Location:420 → 445

zf-H2C2_2; Zinc-finger double domain