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    Prl5a1 prolactin family 5, subfamily a, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 28078, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prl5a1provided by MGI
    Official Full Name
    prolactin family 5, subfamily a, member 1provided by MGI
    Primary source
    MGI:MGI:106332
    See related
    Ensembl:ENSMUSG00000017064 AllianceGenome:MGI:106332
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ghd24; PLP-L; Prlpl; D13Wsu14e; 1600013P04Rik
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in ectoplacental cone; extraembryonic component; placenta; and spongiotrophoblast. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Prl5a1 in Genome Data Viewer
    Location:
    13 A3.1; 13 12.69 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (28326467..28335578)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (28142484..28151595)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene lysophosphatidylcholine acyltransferase 4 pseudogene Neighboring gene prolactin family 4, subfamily a, member 1 Neighboring gene STARR-seq mESC enhancer starr_34023 Neighboring gene STARR-seq mESC enhancer starr_34024 Neighboring gene STARR-seq mESC enhancer starr_34025 Neighboring gene STARR-seq mESC enhancer starr_34026 Neighboring gene ribosomal protein S18, pseudogene 5 Neighboring gene STARR-seq mESC enhancer starr_34028 Neighboring gene predicted gene, 34385

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    prolactin-5A1
    Names
    PRL-like protein L
    growth hormone d24
    placental prolactin-like protein L
    prolactin-like protein L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023746.4NP_076235.1  prolactin-5A1 precursor

      See identical proteins and their annotated locations for NP_076235.1

      Status: PROVISIONAL

      Source sequence(s)
      AK005447
      Consensus CDS
      CCDS26410.1
      UniProtKB/Swiss-Prot
      Q80X20, Q9JII2
      UniProtKB/TrEMBL
      A0A0M6L0X8
      Related
      ENSMUSP00000017208.5, ENSMUST00000017208.5
      Conserved Domains (1) summary
      cl07831
      Location:31229
      growth_hormone_like; Somatotropin/prolactin hormone family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      28326467..28335578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)