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    Ptger3 prostaglandin E receptor 3 (subtype EP3) [ Mus musculus (house mouse) ]

    Gene ID: 19218, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptger3provided by MGI
    Official Full Name
    prostaglandin E receptor 3 (subtype EP3)provided by MGI
    Primary source
    MGI:MGI:97795
    See related
    Ensembl:ENSMUSG00000040016 AllianceGenome:MGI:97795
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EP3; Pgerep3; Ptgerep3
    Summary
    Enables prostaglandin E receptor activity. Involved in positive regulation of fever generation. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; bicarbonate transport; and fever generation. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Orthologous to human PTGER3 (prostaglandin E receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 43.5), adrenal adult (RPKM 43.0) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Ptger3 in Genome Data Viewer
    Location:
    3 H4; 3 81.32 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (157272459..157350392)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (157566821..157644758)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930592C13 gene Neighboring gene STARR-seq mESC enhancer starr_09372 Neighboring gene zinc finger, RAN-binding domain containing 2 Neighboring gene STARR-positive B cell enhancer mm9_chr3:157228208-157228509 Neighboring gene microRNA 186 Neighboring gene STARR-seq mESC enhancer starr_09373 Neighboring gene STARR-seq mESC enhancer starr_09375 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:157279973-157280264 Neighboring gene STARR-seq mESC enhancer starr_09378 Neighboring gene STARR-seq mESC enhancer starr_09380 Neighboring gene predicted gene 5550 Neighboring gene STARR-positive B cell enhancer mm9_chr3:157539858-157540158 Neighboring gene predicted gene 6520

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables prostaglandin E receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables prostaglandin E receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables prostaglandin E receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables prostaglandin E receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within bicarbonate transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to forskolin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in desensitization of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fever generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within fever generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intestine smooth muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intestine smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of circadian sleep/wake cycle, wakefulness ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of forebrain neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gastric acid secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of gastrin-induced gastric acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of norepinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of colon smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fever generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gastric mucosal blood circulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inhibitory G protein-coupled receptor phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of myofibroblast contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle contraction involved in micturition ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of urine volume IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of circadian sleep/wake cycle, wakefulness ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of norepinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in urinary bladder smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in proximal neuron projection ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    prostaglandin E2 receptor EP3 subtype
    Names
    PGE receptor EP3 subtype
    PGE2 receptor EP3 subtype
    prostaglandin E receptor EP3 subtype
    prostanoid EP3 receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359745.2NP_001346674.1  prostaglandin E2 receptor EP3 subtype isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132240, AC141480
      Consensus CDS
      CCDS89716.1
      UniProtKB/Swiss-Prot
      P30557
      UniProtKB/TrEMBL
      G3UYL9
      Related
      ENSMUSP00000134137.2, ENSMUST00000173533.2
      Conserved Domains (2) summary
      cd14964
      Location:2852
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:26335
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. NM_011196.4NP_035326.2  prostaglandin E2 receptor EP3 subtype isoform 2

      See identical proteins and their annotated locations for NP_035326.2

      Status: VALIDATED

      Source sequence(s)
      AC132240, AC141480
      Consensus CDS
      CCDS17932.1
      UniProtKB/Swiss-Prot
      P30557
      UniProtKB/TrEMBL
      Q6PDF2
      Related
      ENSMUSP00000043302.7, ENSMUST00000041175.13
      Conserved Domains (1) summary
      pfam00001
      Location:42323
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      157272459..157350392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501140.4XP_006501203.1  prostaglandin E2 receptor EP3 subtype isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:2753
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:26278
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. XM_011240038.3XP_011238340.1  prostaglandin E2 receptor EP3 subtype isoform X1

      UniProtKB/Swiss-Prot
      P30557
      Conserved Domains (2) summary
      cd14964
      Location:2753
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:26298
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily