Cbr3 carbonyl reductase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cbr3provided by MGI
Official Full Name: carbonyl reductase 3provided by MGI
Primary source: MGI:MGI:1309992
See related: Ensembl:ENSMUSG00000022947 AllianceGenome:MGI:1309992
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110001J05Rik
Summary: Predicted to enable NADPH binding activity; NADPH dehydrogenase (quinone) activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in cognition and phylloquinone catabolic process. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Orthologous to human CBR3 (carbonyl reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in stomach adult (RPKM 117.7), colon adult (RPKM 22.3) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C4; 16 54.58 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (93480107..93487879)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (93683219..93690991)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C81353 (e-PCR)
- UniSTS:160597

RH127062 (e-PCR)
- UniSTS:209251

G67813 (e-PCR)
- UniSTS:226159

G67814 (e-PCR)
- UniSTS:226160

Cbr3 (e-PCR), detects polymorphism
- UniSTS:525984

Cbr3 (e-PCR), detects polymorphism
- UniSTS:259050

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-keto sterol reductase activity	IEA Inferred from Electronic Annotation more info
enables 3-keto sterol reductase activity	ISO Inferred from Sequence Orthology more info
enables NADPH binding	IEA Inferred from Electronic Annotation more info
enables NADPH binding	ISO Inferred from Sequence Orthology more info
enables NADPH dehydrogenase (quinone) activity	ISO Inferred from Sequence Orthology more info
enables NADPH dehydrogenase (quinone) activity	ISS Inferred from Sequence or Structural Similarity more info
enables carbonyl reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonyl reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables carbonyl reductase (NADPH) activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cognition	IEA Inferred from Electronic Annotation more info
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in phylloquinone catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phylloquinone catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carbonyl reductase [NADPH] 3

Names: NADPH-dependent carbonyl reductase 3; quinone reductase CBR3

NP_766635.1

EC 1.1.1.184

EC 1.6.5.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.