Crabp1 cellular retinoic acid binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crabp1provided by RGD
Official Full Name: cellular retinoic acid binding protein 1provided by RGD
Primary source: RGD:2400
See related: EnsemblRapid:ENSRNOG00000023633 AllianceGenome:RGD:2400
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables retinoic acid binding activity. Predicted to be involved in fatty acid transport. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human CRABP1 (cellular retinoic acid binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Uterus (RPKM 65.9), Testes (RPKM 55.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (64047431..64055469)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (55138363..55159360)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (59344097..59352135)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRABP-I expression controls the intracellular availability of retinoic acid and may be an important regulator of neuronal differentiation processes in the aged hippocampus.
Title: A mid-life vitamin A supplementation prevents age-related spatial memory deficits and hippocampal neurogenesis alterations through CRABP-I.
both CRABP II and CRABP I proteins and the mRNAs that encode them are present in postnatal rat olfactory epithelium
Title: Expression of the cellular retinoic acid binding proteins, type II and type I, in mature rat olfactory epithelium.

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General gene information

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Markers

Crabp1 (e-PCR), detects polymorphism
- UniSTS:470553

Crabp1 (e-PCR), detects polymorphism
- UniSTS:141393

Crabp1 (e-PCR), detects polymorphism
- UniSTS:525706

AA875025 (e-PCR)
- UniSTS:261002

Crabp1 (e-PCR), detects polymorphism
- UniSTS:186507

Crabp1 (e-PCR), detects polymorphism
- UniSTS:526991

Crabp1 (e-PCR), detects polymorphism
- UniSTS:496536

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables retinal binding	IEA Inferred from Electronic Annotation more info
enables retinoic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables retinoic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables retinol binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cellular retinoic acid-binding protein 1

Names: CRABP-I; cellular retinoic acid-binding protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.