Khdc1b KH domain containing 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Khdc1bprovided by MGI
Official Full Name: KH domain containing 1Bprovided by MGI
Primary source: MGI:MGI:2138477
See related: Ensembl:ENSMUSG00000085079 AllianceGenome:MGI:2138477
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Khdc1; Khdc1c
Summary: Enables RNA binding activity and identical protein binding activity. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process. Located in cytoplasm. Is expressed in early conceptus and ovary. Orthologous to several human genes including KHDC1L (KH domain containing 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in ovary adult (RPKM 1.6) and genital fat pad adult (RPKM 0.1) See more
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Genomic context

Location:: 1 A4; 1 6.64 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (21453780..21456608)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (21383556..21386384)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that KHDC1B, via its interaction with mCEPB1, may regulate translation of mRNA targets required for oocyte maturation.
Title: KHDC1B is a novel CPEB binding partner specifically expressed in mouse oocytes and early embryos.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

AU015226 (e-PCR)
- UniSTS:207132

C86372 (e-PCR)
- UniSTS:207137

RH127167 (e-PCR)
- UniSTS:207138

AU024076 (e-PCR)
- UniSTS:185433

Khdc1b (e-PCR), detects polymorphism
- UniSTS:548007

Khdc1b (e-PCR), detects polymorphism
- UniSTS:548008

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: KH homology domain-containing protein 1B

Names: KH homology domain containing 1; KH homology domain containing 1B; oocyte-specific Khdc1; peptidase M20 domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.