Cyth1 cytohesin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyth1provided by MGI
Official Full Name: cytohesin 1provided by MGI
Primary source: MGI:MGI:1334257
See related: Ensembl:ENSMUSG00000017132 AllianceGenome:MGI:1334257
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CLM1; CTH-1; CYTIP; Pscd1
Summary: Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within establishment of epithelial cell polarity. Located in bicellular tight junction; cytoplasmic side of plasma membrane; and cytosol. Is expressed in nervous system. Orthologous to human CYTH1 (cytohesin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 19.7), frontal lobe adult (RPKM 16.5) and 27 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 11 E2; 11 82.96 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (118054996..118139452, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (118164170..118248616, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A natural loss-of-function deletion of the cytohesin 1 (Cyth1) gene in BALB/cByJ mice does not impact cardiomyocyte polyploidy.
Title: A natural loss-of-function deletion of the cytohesin 1 (Cyth1) gene in BALB/cByJ mice does not impact cardiomyocyte polyploidy.
Cytohesin-1 is required for Schwann cell migration and that phosphorylation of cytohesin-1 at the Tyr-382 position is important for migration.
Title: Signaling through Arf6 guanine-nucleotide exchange factor cytohesin-1 regulates migration in Schwann cells.
Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development.
Title: Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development.
cytohesin inhibition has an antiproliferative effect in gefitinib-resistant lung cancer cells
Title: Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells.
demonstrate an essential role of cytohesin-1/RhoA during ameboid migration in the presence of integrins
Title: Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (1) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within establishment of epithelial cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of presynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: cytohesin-1

Names: PH, SEC7 and coiled-coil domain-containing protein 1; SEC7 homolog A; mSec7-1; pleckstrin homology, Sec7 and coiled-coil domains 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001112699.2 → NP_001106169.1 cytohesin-1 isoform 2

See identical proteins and their annotated locations for NP_001106169.1

Status: VALIDATED

Source sequence(s)

AL591109, AL591204, AL591404

Consensus CDS

CCDS48997.1

UniProtKB/TrEMBL

Q3T9T9, Q8K3E8

Related

ENSMUSP00000017276.8, ENSMUST00000017276.14

Conserved Domains (2) summary

cd01252
Location:259 → 378

PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain

pfam01369
Location:62 → 244

Sec7; Sec7 domain
NM_001112700.2 → NP_001106170.1 cytohesin-1 isoform 3

See identical proteins and their annotated locations for NP_001106170.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longest isoform (3).

Source sequence(s)

AL591109, AL591204

UniProtKB/TrEMBL

Q3T9T9, Q3TZ02

Conserved Domains (4) summary

cd01252
Location:261 → 381

PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain

pfam00169
Location:265 → 379

PH; PH domain

pfam01369
Location:64 → 246

Sec7; Sec7 domain

cl19219
Location:8 → 90

DUF342; Protein of unknown function (DUF342)
NM_001378885.1 → NP_001365814.1 cytohesin-1 isoform 4

Status: VALIDATED

Source sequence(s)

AL591109, AL591204

UniProtKB/TrEMBL

B1AQE4, Q3T9T9

Related

ENSMUSP00000114792.3, ENSMUST00000151165.3

Conserved Domains (2) summary

cd01252
Location:261 → 380

PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain

pfam01369
Location:64 → 246

Sec7; Sec7 domain
NM_001378886.1 → NP_001365815.1 cytohesin-1 isoform 5

Status: VALIDATED

Source sequence(s)

AL591109, AL591204

UniProtKB/TrEMBL

Q3T9T9

Conserved Domains (2) summary

cd01252
Location:200 → 319

PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain

pfam01369
Location:3 → 185

Sec7; Sec7 domain
NM_001378887.1 → NP_001365816.1 cytohesin-1 isoform 6

Status: VALIDATED

Source sequence(s)

AL591109, AL591404

Conserved Domains (1) summary

pfam01369
Location:62 → 244

Sec7; Sec7 domain
NM_001378888.1 → NP_001365817.1 cytohesin-1 isoform 7

Status: VALIDATED

Source sequence(s)

AL591109

Conserved Domains (1) summary

pfam01369
Location:3 → 185

Sec7; Sec7 domain
NM_011180.4 → NP_035310.2 cytohesin-1 isoform 1

See identical proteins and their annotated locations for NP_035310.2

Status: VALIDATED

Source sequence(s)

AL591109, AL591204, AL591404

UniProtKB/Swiss-Prot

O88817, Q76MU4, Q9QX11

UniProtKB/TrEMBL

Q3T9T9

Conserved Domains (2) summary

cd01252
Location:259 → 379

PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain

pfam01369
Location:62 → 244

Sec7; Sec7 domain

RNA

NR_166155.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL591109, AL591204

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

118054996..118139452 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532519.5 → XP_006532582.1 cytohesin-1 isoform X1

See identical proteins and their annotated locations for XP_006532582.1

UniProtKB/TrEMBL

Q3T9T9

Conserved Domains (2) summary

cd01252
Location:200 → 320

PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain

pfam01369
Location:3 → 185

Sec7; Sec7 domain
XM_011248805.4 → XP_011247107.1 cytohesin-1 isoform X2

Conserved Domains (1) summary

pfam01369
Location:64 → 246

Sec7; Sec7 domain