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    Tbata thymus, brain and testes associated [ Mus musculus (house mouse) ]

    Gene ID: 65971, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tbataprovided by MGI
    Official Full Name
    thymus, brain and testes associatedprovided by MGI
    Primary source
    MGI:MGI:1923820
    See related
    Ensembl:ENSMUSG00000020096 AllianceGenome:MGI:1923820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Titest; Spatial; 1700021K02Rik
    Summary
    This gene encodes a putative transcription factor that is highly expressed in thymic cortical stromal cells, and may be involved in T-cell development. Its expression is developmentally regulated in the testis, where it is restricted to the haploid round spermatids during spermatogenesis, and thus this gene may also have a role in the control of male germ cell development. Alternative splicing of this gene results in two sets of transcript variants: the variants containing 5 additional exons at the 3' end encode long isoforms that are highly expressed in the testis, while the variants lacking the 3' end exons encode short isoforms that are highly expressed in the thymus. Most of the transcripts encoding the short isoforms have been shown to initiate translation from non-AUG (CUG) start sites. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis adult (RPKM 135.3) and thymus adult (RPKM 109.1) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tbata in Genome Data Viewer
    Location:
    10 B4; 10 32.16 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (61007743..61024620)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (61171964..61188841)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 Neighboring gene sphingosine phosphate lyase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8337 Neighboring gene STARR-positive B cell enhancer mm9_chr10:60610293-60610594 Neighboring gene STARR-seq mESC enhancer starr_26826 Neighboring gene STARR-positive B cell enhancer mm9_chr10:60662268-60662569 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 14 Neighboring gene predicted gene, 29861 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:60697146-60697393 Neighboring gene perforin 1 (pore forming protein)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in spermatid differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein TBATA
    Names
    protein SPATIAL
    stromal protein associated with thymii and lymph node
    stromal protein associated with thymii and lymph nodes
    thymus and testis specific nuclear protein
    thymus, brain and testes-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017407.1NP_001017407.1  protein TBATA isoform 5

      See identical proteins and their annotated locations for NP_001017407.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate, in-frame acceptor splice site in one of the coding exons compared to transcript variant 3, resulting in an isoform (5, also known as Spatial-gamma) that is missing an internal segment compared to short isoform 3. This variant initiates translation from a non-AUG (CUG) start site and is highly expressed in the thymus.
      Source sequence(s)
      AF257503, AJ249392
      UniProtKB/Swiss-Prot
      Q7TSD4
      UniProtKB/TrEMBL
      Q91YF1
      Conserved Domains (1) summary
      pfam15256
      Location:87196
      SPATIAL; SPATIAL
    2. NM_001017409.1NP_001017409.1  protein TBATA isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate acceptor splice site in one of the coding exons and in the last exon, compared to transcript variant 3. The encoded isoform (6, also known as Spatial-beta) is missing an internal segment and has a different C-terminus compared to short isoform 3. This variant initiates translation from a non-AUG (CUG) start site and is highly expressed in the thymus.
      Source sequence(s)
      AJ249392, AY243457, AY243459
      UniProtKB/TrEMBL
      Q91YF1
      Conserved Domains (1) summary
      pfam15256
      Location:87155
      SPATIAL; SPATIAL
    3. NM_001017419.2NP_001017419.1  protein TBATA isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site in one of the coding exons compared to transcript variant 1, resulting in an isoform (2, also known as Spatial-delta) that is missing an internal segment compared to long isoform 1, and like the latter, it is highly expressed in the testis.
      Source sequence(s)
      AF521591, AK132793, AW490515
      Consensus CDS
      CCDS48572.1
      UniProtKB/Swiss-Prot
      Q7TSD4
      Related
      ENSMUSP00000113902.2, ENSMUST00000122261.8
      Conserved Domains (1) summary
      pfam15256
      Location:82281
      SPATIAL; SPATIAL
    4. NM_001017433.2NP_001017433.1  protein TBATA isoform 1

      See identical proteins and their annotated locations for NP_001017433.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1, also known as Spatial-epsilon) that is highly expressed in the testis.
      Source sequence(s)
      AF521592, AK132793, AW490515
      Consensus CDS
      CCDS23873.1
      UniProtKB/Swiss-Prot
      B2ZA64, Q6XBG6, Q6XBG7, Q6XBG8, Q7TSD4, Q7TSD5, Q8BYU0, Q9EQE4, Q9EQE5
      Related
      ENSMUSP00000036422.6, ENSMUST00000035894.12
      Conserved Domains (1) summary
      pfam15256
      Location:82315
      SPATIAL; SPATIAL
    5. NM_001017441.2NP_001017441.2  protein TBATA isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, 5' coding region and mid-coding region, compared to variant 3. The encoded isoform (4) is shorter and has a different N-terminus, compared to short isoform 3.
      Source sequence(s)
      AJ249392, AK132793
      Consensus CDS
      CCDS23874.2
      UniProtKB/TrEMBL
      Q91YF1
      Related
      ENSMUSP00000113253.2, ENSMUST00000121297.8
      Conserved Domains (1) summary
      pfam15256
      Location:82191
      SPATIAL; SPATIAL
    6. NM_023064.3NP_075551.3  protein TBATA isoform 3

      See identical proteins and their annotated locations for NP_075551.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes the longest of the short isoforms (3, also known as Spatial-alpha). It initiates translation from a non-AUG (CUG) start site and is highly expressed in the thymus.
      Source sequence(s)
      AF257502, AJ249392
      Consensus CDS
      CCDS48573.1
      UniProtKB/Swiss-Prot
      Q7TSD4
      UniProtKB/TrEMBL
      G5E8I6, Q91YF1
      Conserved Domains (1) summary
      pfam15256
      Location:87230
      SPATIAL; SPATIAL

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      61007743..61024620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)